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Wellbutrin and Zecuity drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Wellbutrin (bupropion hydrochloride) and Zecuity (sumatriptan succinate). Common drug interactions include application site discolouration among females and application site dryness among males.

The phase IV clinical study analyzes what interactions people have when they take Wellbutrin and Zecuity. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,110 Wellbutrin users. Check the latest studies of Wellbutrin.

What is Zecuity?

Zecuity has active ingredients of sumatriptan succinate. eHealthMe is studying from 3,104 Zecuity users. Check the latest studies of Zecuity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

24 people who take Wellbutrin and Zecuity together, and have interactions are studied.

Wellbutrin and Zecuity drug interactions.

What are the common drug interactions of Wellbutrin and Zecuity, by gender? *:

female:

  1. Application site discolouration
  2. Application site irritation
  3. Application site pruritus (application site severe itching of the skin)
  4. Application site paraesthesia (abnormal skin sensation of tingling, tickling, prickling, pricking, or burning felt at application site)
  5. Application site warmth
  6. Application site inflammation
  7. Application site urticaria
  8. Application site discomfort
  9. Drug ineffective
  10. Application site scar

male:

  1. Application site dryness
  2. Application site exfoliation (application site removal of the oldest dead skin cells on the skin's outermost surface)
  3. Application site burn
  4. Application site discolouration
  5. Application site erythema (redness of the skin at application site)
  6. Application site paraesthesia (abnormal skin sensation of tingling, tickling, prickling, pricking, or burning felt at application site)
  7. Application site warmth

What are the common drug interactions of Wellbutrin and Zecuity, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Drug ineffective
  2. Headache (pain in head)
  3. Application site burn
  4. Application site discolouration
  5. Application site erythema (redness of the skin at application site)
  6. Application site irritation
  7. Application site pain
  8. Application site paraesthesia (abnormal skin sensation of tingling, tickling, prickling, pricking, or burning felt at application site)
  9. Application site pruritus (application site severe itching of the skin)
  10. Application site rash

30-39:

  1. Application site pain
  2. Application site erythema (redness of the skin at application site)
  3. Application site discolouration
  4. Application site irritation
  5. Application site pruritus (application site severe itching of the skin)
  6. Application site warmth
  7. Application site burn
  8. Application site discomfort
  9. Application site papules (solid elevation of skin with no visible fluid at application site)
  10. Application site paraesthesia (abnormal skin sensation of tingling, tickling, prickling, pricking, or burning felt at application site)

40-49:

  1. Application site burn
  2. Application site discolouration
  3. Application site erythema (redness of the skin at application site)
  4. Application site paraesthesia (abnormal skin sensation of tingling, tickling, prickling, pricking, or burning felt at application site)
  5. Application site warmth
  6. Application site inflammation
  7. Application site pain
  8. Application site pruritus (application site severe itching of the skin)
  9. Application site dryness
  10. Application site discomfort

50-59:

  1. Application site papules (solid elevation of skin with no visible fluid at application site)
  2. Application site scar
  3. Application site discomfort
  4. Application site paraesthesia (abnormal skin sensation of tingling, tickling, prickling, pricking, or burning felt at application site)
  5. Application site warmth
  6. Drug ineffective
  7. Application site vesicles (small bubble within a cell at application site)
  8. Sunburn
  9. Application site exfoliation (application site removal of the oldest dead skin cells on the skin's outermost surface)
  10. Application site inflammation

60+:

  1. Application site burn
  2. Application site erythema (redness of the skin at application site)
  3. Application site scar

What are the existing conditions these people have? *

  1. Migraine (headache): 20 people, 83.33%
  2. Headache (pain in head): 4 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Wellbutrin and Zecuity?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Wellbutrin and Zecuity:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Wellbutrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zecuity:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Wellbutrin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zecuity and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride and sumatriptan succinate (the active ingredients of Wellbutrin and Zecuity, respectively), and Wellbutrin and Zecuity (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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