Hydrochlorothiazide and Water retention - a phase IV clinical study of FDA data

Summary:

Water retention is reported as a side effect among people who take Hydrochlorothiazide (hydrochlorothiazide), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Aspirin, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Water retention when taking Hydrochlorothiazide. It is created by eHealthMe based on reports of 177,544 people who have side effects when taking Hydrochlorothiazide from the FDA, and is updated regularly.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,186 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

What is Water retention?

Water retention is found to be associated with 2,113 drugs and 2,453 conditions by eHealthMe. Check the latest studies of Water retention.

On Feb, 08, 2026

177,544 people reported to have side effects when taking Hydrochlorothiazide.
Among them, 1,035 people (0.58%) have Water retention.

Could Hydrochlorothiazide cause Water retention?

Among these 1,035 people:

How long have people been on Hydrochlorothiazide when they have Water retention? *

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What is the gender of people who have Water retention when taking Hydrochlorothiazide? *

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What is the age of people who have Water retention when taking Hydrochlorothiazide? *

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* Approximation only. Some reports may have incomplete information.

Do you take Hydrochlorothiazide and have Water retention?

- Check whether Water retention is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrochlorothiazide:

Hydrochlorothiazide (182,186 reports)

Water retention treatments and more:

Water retention (79,655 reports)

How severe was Water retention and when was it recovered:

Water retention in Hydrochlorothiazide

Expand to all the drugs that have ingredients of hydrochlorothiazide:

Water retention and drugs with ingredients of hydrochlorothiazide (1,194 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydrochlorothiazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Water retention:

Water retention (2,113 drugs)

Browse all the conditions that are associated with Water retention:

Water retention (2,453 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Hydrochlorothiazide) and Hydrochlorothiazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.