Hydrocodone and Pulmonary hypertension - a phase IV clinical study of FDA data

Summary:

Pulmonary hypertension is reported as a side effect among people who take Hydrocodone (hydrocodone bitartrate; ibuprofen), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Furosemide, and have High blood pressure.

The phase IV clinical study analyzes which people have Pulmonary hypertension when taking Hydrocodone. It is created by eHealthMe based on reports of 13,053 people who have side effects when taking Hydrocodone from the FDA, and is updated regularly.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

What is Pulmonary hypertension?

Pulmonary hypertension (increase in blood pressure in the lung artery) is found to be associated with 1,427 drugs and 1,299 conditions by eHealthMe. Check the latest studies of Pulmonary hypertension.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

13,053 people reported to have side effects when taking Hydrocodone.
Among them, 15 people (0.11%) have Pulmonary hypertension.

Could Hydrocodone cause Pulmonary hypertension?

Among these 15 people:

How long have people been on Hydrocodone when they have Pulmonary hypertension? *

What is the gender of people who have Pulmonary hypertension when taking Hydrocodone? *

female: 84.62 %
male: 15.38 %

What is the age of people who have Pulmonary hypertension when taking Hydrocodone? *

What are other drugs people take besides Hydrocodone? *

What are other side effects people have besides Pulmonary hypertension? *

Back Pain: 5 people, 33.33%
Pulmonary Embolism (blockage of the main artery of the lung): 4 people, 26.67%
Arrhythmias (irregular heartbeat): 4 people, 26.67%
Mitral Valve Incompetence (inefficient heart valve): 4 people, 26.67%
Tricuspid Valve Incompetence (inefficient heart valve): 4 people, 26.67%
Chest Pain: 4 people, 26.67%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 3 people, 20.00%
Blood Potassium Decreased: 3 people, 20.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 20.00%
Oesophagitis (inflammation of oesophagus): 3 people, 20.00%

What are the existing conditions these people have? *

Pain: 4 people, 26.67%
Depression: 4 people, 26.67%
Diabetes: 4 people, 26.67%
High Blood Pressure: 4 people, 26.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 20.00%
Cardiac Disorder: 3 people, 20.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 20.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 20.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 20.00%
Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrocodone and have Pulmonary hypertension?

- Check whether Pulmonary hypertension is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrocodone:

Hydrocodone (13,115 reports)

Pulmonary hypertension treatments and more:

Pulmonary hypertension (98,337 reports)

How severe was Pulmonary hypertension and when was it recovered:

Pulmonary hypertension in Hydrocodone

Expand to all the drugs that have ingredients of hydrocodone bitartrate; ibuprofen:

Pulmonary hypertension and drugs with ingredients of hydrocodone bitartrate; ibuprofen

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydrocodone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pulmonary hypertension:

Pulmonary hypertension (1,427 drugs)

Browse all the conditions that are associated with Pulmonary hypertension:

Pulmonary hypertension (1,299 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrocodone bitartrate; ibuprofen (the active ingredients of Hydrocodone) and Hydrocodone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.