Hydroxyurea and Death - a phase IV clinical study of FDA data

Summary:

Death is reported as a side effect among people who take Hydroxyurea (hydroxyurea), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Jakafi, and have Primary myelofibrosis.

The study is created by eHealthMe based on reports of 16,937 people who have side effects when taking Hydroxyurea from the FDA, and is updated regularly.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,238 Hydroxyurea users. Check the latest studies of Hydroxyurea.

On Jan, 22, 2026

16,937 people reported to have side effects when taking Hydroxyurea.
Among them, 754 people (4.45%) died.

Among these 754 people:

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydroxyurea:

Hydroxyurea (17,238 reports)

Expand to all the drugs that have ingredients of hydroxyurea:

Death and drugs with ingredients of hydroxyurea (950 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Hydroxyurea side effects:

Browse all side effects of Hydroxyurea:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Death:

Revlimid side effect: Death (26,599 reports)
Oxycontin side effect: Death (26,234 reports)
Eliquis side effect: Death (20,064 reports)
Percocet side effect: Death (18,245 reports)
Aspirin side effect: Death (17,506 reports)
Dilaudid side effect: Death (16,039 reports)
Duragesic side effect: Death (15,973 reports)
Prolia side effect: Death (15,556 reports)
Aranesp side effect: Death (15,538 reports)
Ms contin side effect: Death (14,944 reports)

Browse all the drugs that are associated with Death:

Death (3,174 drugs)

Common conditions associated with Death:

Multiple myeloma: 23,142 reports
Pain exacerbated: 20,012 reports
Pain: 19,371 reports
Pain relief: 18,934 reports
Acupuncture and pain: 17,984 reports
Plasma cell myeloma: 17,926 reports
Pulmonary arterial hypertension: 17,771 reports
Primary pulmonary hypertension: 16,747 reports
Myeloma - multiple: 15,037 reports
Sporadic primary pulmonary hypertension: 13,754 reports

Browse all the conditions that are associated with Death:

Death (3,686 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydroxyurea (the active ingredients of Hydroxyurea) and Hydroxyurea (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.