Hydroxyurea and Metabolic acidosis - a phase IV clinical study of FDA data

Summary:

Metabolic acidosis is reported as a side effect among people who take Hydroxyurea (hydroxyurea), especially for people who are male, 40-49 old, have been taking the drug for 6 - 12 months also take Didanosine, and have Hiv infection.

The phase IV clinical study analyzes which people have Metabolic acidosis when taking Hydroxyurea. It is created by eHealthMe based on reports of 16,937 people who have side effects when taking Hydroxyurea from the FDA, and is updated regularly.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,240 Hydroxyurea users. Check the latest studies of Hydroxyurea.

What is Metabolic acidosis?

Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body) is found to be associated with 1,414 drugs and 1,660 conditions by eHealthMe. Check the latest studies of Metabolic acidosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

16,937 people reported to have side effects when taking Hydroxyurea.
Among them, 47 people (0.28%) have Metabolic acidosis.

Could Hydroxyurea cause Metabolic acidosis?

Among these 47 people:

How long have people been on Hydroxyurea when they have Metabolic acidosis? *

What is the gender of people who have Metabolic acidosis when taking Hydroxyurea? *

female: 35.56 %
male: 64.44 %

What is the age of people who have Metabolic acidosis when taking Hydroxyurea? *

What are other drugs people take besides Hydroxyurea? *

What are other side effects people have besides Metabolic acidosis? *

Hyperkalemia (damage to or disease of the kidney): 14 people, 29.79%
Hypotension (abnormally low blood pressure): 11 people, 23.40%
Dyspnea (difficult or laboured breathing): 10 people, 21.28%
Nausea (feeling of having an urge to vomit): 6 people, 12.77%
Multi-Organ Failure (multisystem organ failure): 6 people, 12.77%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 6 people, 12.77%
Fever: 5 people, 10.64%
Fanconi Syndrome Acquired (self developed genetic disease of kidney damage due to defective transport system): 5 people, 10.64%
Hypercreatininaemia (high levels of creatine in the blood): 5 people, 10.64%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 5 people, 10.64%

What are the existing conditions these people have? *

Hiv Infection: 9 people, 19.15%
High Blood Pressure: 5 people, 10.64%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 3 people, 6.38%
Chronic Myelomonocytic Leukaemia (cancers of the blood-forming cells of the bone marrow): 2 people, 4.26%
Abdominal Pain: 2 people, 4.26%
Primary Myelofibrosis (primary disorder of the bone marrow): 2 people, 4.26%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 4.26%
Pneumonia: 1 person, 2.13%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 1 person, 2.13%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 1 person, 2.13%

* Approximation only. Some reports may have incomplete information.

Do you take Hydroxyurea and have Metabolic acidosis?

- Check whether Metabolic acidosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydroxyurea:

Hydroxyurea (17,240 reports)

Browse all side effects of Hydroxyurea:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Metabolic acidosis:

Metabolic acidosis (1,414 drugs)

Browse all the conditions that are associated with Metabolic acidosis:

Metabolic acidosis (1,660 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydroxyurea (the active ingredients of Hydroxyurea) and Hydroxyurea (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.