Hydroxyzine and Hyperbilirubinaemia - a phase IV clinical study of FDA data

Summary:

Hyperbilirubinaemia is reported as a side effect among people who take Hydroxyzine (hydroxyzine hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Furosemide, and have High blood pressure.

The phase IV clinical study analyzes which people have Hyperbilirubinaemia when taking Hydroxyzine. It is created by eHealthMe based on reports of 51,890 people who have side effects when taking Hydroxyzine from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,070 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is Hyperbilirubinaemia?

Hyperbilirubinaemia (excess of bilirubin in the blood) is found to be associated with 905 drugs and 1,074 conditions by eHealthMe. Check the latest studies of Hyperbilirubinaemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

51,890 people reported to have side effects when taking Hydroxyzine.
Among them, 94 people (0.18%) have Hyperbilirubinaemia.

Could Hydroxyzine cause Hyperbilirubinaemia?

Among these 94 people:

How long have people been on Hydroxyzine when they have Hyperbilirubinaemia? *

What is the gender of people who have Hyperbilirubinaemia when taking Hydroxyzine? *

female: 27.38 %
male: 72.62 %

What is the age of people who have Hyperbilirubinaemia when taking Hydroxyzine? *

What are other drugs people take besides Hydroxyzine? *

What are other side effects people have besides Hyperbilirubinaemia? *

Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 31 people, 32.98%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 18 people, 19.15%
Pneumonia: 12 people, 12.77%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 10 people, 10.64%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 9 people, 9.57%
Lung Infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung): 8 people, 8.51%
Pulmonary Valve Stenosis (heart valve disorder in which outflow of blood from the right ventricle of the heart is obstructed at the level of the pulmonic valve): 8 people, 8.51%
Pulmonary Valve Incompetence: 8 people, 8.51%
Drug Exposure During Pregnancy: 8 people, 8.51%
Premature Baby: 8 people, 8.51%

What are the existing conditions these people have? *

High Blood Pressure: 34 people, 36.17%
Hepatocellular Carcinoma (liver cancer): 27 people, 28.72%
Diabetes: 27 people, 28.72%
Ascites (accumulation of fluid in the abdominal cavity): 26 people, 27.66%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 22 people, 23.40%
Depression: 17 people, 18.09%
Postpartum Depression (depression suffered by a mother following childbirth): 8 people, 8.51%
Cholera (infection of the small intestine caused by the bacterium vibrio cholerae): 7 people, 7.45%
Dyslipidaemia (abnormal amount of lipids): 7 people, 7.45%
Staphylococcal Infection (an infection with staphylococcus bacteria): 7 people, 7.45%

* Approximation only. Some reports may have incomplete information.

Do you take Hydroxyzine and have Hyperbilirubinaemia?

- Check whether Hyperbilirubinaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydroxyzine:

Hydroxyzine (54,070 reports)

Browse all side effects of Hydroxyzine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperbilirubinaemia:

Hyperbilirubinaemia (905 drugs)

Browse all the conditions that are associated with Hyperbilirubinaemia:

Hyperbilirubinaemia (1,074 conditions)

Related publications that referenced our studies

Ate? ?, Arikan MF, Kaplan M, Altay M, "Hydroxyzine induced pancytopenia and petechial rashes: a rare complication", Journal Of Contemporary Medicine, 2017 Jan .
Ate? ?, Arikan MF, Kaplan M, Altay M, "Hydroxyzine induced pancytopenia and petechial rashes: a rare complication", Journal Of Contemporary Medicine, 2017 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on hydroxyzine hydrochloride (the active ingredients of Hydroxyzine) and Hydroxyzine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.