Hysingla and Joint pain - a phase IV clinical study of FDA data

Summary:

Joint pain is reported as a side effect among people who take Hysingla (hydrocodone bitartrate), especially for people who are female, 40-49 old, have been taking the drug for 1 - 6 months also take Palladone, and have Pain.

The phase IV clinical study analyzes which people have Joint pain when taking Hysingla. It is created by eHealthMe based on reports of 32,589 people who have side effects when taking Hysingla from the FDA, and is updated regularly.

What is Hysingla?

Hysingla has active ingredients of hydrocodone bitartrate. eHealthMe is studying from 32,609 Hysingla users. Check the latest studies of Hysingla.

What is Joint pain?

Joint pain is found to be associated with 3,333 drugs and 5,203 conditions by eHealthMe. Check the latest studies of Joint pain.

On Apr, 24, 2026

32,589 people reported to have side effects when taking Hysingla.
Among them, 42 people (0.13%) have Joint pain.

Among these 42 people:

How long have people been on Hysingla when they have Joint pain? *

What is the gender of people who have Joint pain when taking Hysingla? *

female: 59.52 %
male: 40.48 %

What is the age of people who have Joint pain when taking Hysingla? *

What are other drugs people take besides Hysingla? *

Palladone: 16 people, 38.10%
Dhc Plus: 15 people, 35.71%
Hydrocodone Bitartrate And Acetaminophen: 14 people, 33.33%
Oxycontin: 10 people, 23.81%
Dilaudid: 9 people, 21.43%
Lyrica: 7 people, 16.67%
Ondansetron: 6 people, 14.29%
Oxycodone: 6 people, 14.29%
Plaquenil: 5 people, 11.90%
Diclofenac: 5 people, 11.90%

What are other side effects people have besides Joint pain? *

Pain: 25 people, 59.52%
Drug Dependence: 20 people, 47.62%
Back Pain: 14 people, 33.33%
Fatigue (feeling of tiredness): 14 people, 33.33%
Pain In Extremity: 14 people, 33.33%
Stress And Anxiety: 13 people, 30.95%
Headache (pain in head): 12 people, 28.57%
Malaise (a feeling of general discomfort or uneasiness): 9 people, 21.43%
Insomnia (sleeplessness): 8 people, 19.05%
Memory Loss: 8 people, 19.05%

What are the existing conditions these people have? *

Pain: 17 people, 40.48%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 14.29%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 4 people, 9.52%
Cutaneous Lupus Erythematosus (own immune system attacks various cells causing a wide variety of signs and symptoms): 4 people, 9.52%
Urethral Stricture Traumatic (narrowing of the urethra caused by-injury): 4 people, 9.52%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 7.14%
Gout (uric acid crystals building up in the body): 3 people, 7.14%
Itching: 3 people, 7.14%
Neuropathy Peripheral (surface nerve damage): 3 people, 7.14%
Wrist Fracture: 2 people, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Hysingla and have Joint pain?

- Check whether Joint pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hysingla:

Hysingla (32,609 reports)

Joint pain treatments and more:

Joint pain (542,934 reports)

Browse all side effects of Hysingla:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint pain:

Joint pain (3,333 drugs)

Browse all the conditions that are associated with Joint pain:

Joint pain (5,203 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrocodone bitartrate (the active ingredients of Hysingla) and Hysingla (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.