Hyzaar and C. diff - a phase IV clinical study of FDA data

Summary:

C. diff is reported as a side effect among people who take Hyzaar (hydrochlorothiazide; losartan potassium), especially for people who are male, 60+ old, have been taking the drug for 6 - 12 months also take Ambien, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have C. diff when taking Hyzaar. It is created by eHealthMe based on reports of 15,960 people who have side effects when taking Hyzaar from the FDA, and is updated regularly.

What is Hyzaar?

Hyzaar has active ingredients of hydrochlorothiazide; losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 16,614 Hyzaar users. Check the latest studies of Hyzaar.

What is C. diff?

C. diff is found to be associated with 1,601 drugs and 1,776 conditions by eHealthMe. Check the latest studies of C. diff.

On Apr, 27, 2026

15,960 people reported to have side effects when taking Hyzaar.
Among them, 10 people (0.06%) have C. diff.

Among these 10 people:

How long have people been on Hyzaar when they have C. diff? *

What is the gender of people who have C. diff when taking Hyzaar? *

female: 50 %
male: 50 %

What is the age of people who have C. diff when taking Hyzaar? *

What are other drugs people take besides Hyzaar? *

What are other side effects people have besides C. diff? *

Acute Kidney Failure: 4 people, 40.00%
Nausea (feeling of having an urge to vomit): 3 people, 30.00%
Nausea And Vomiting: 3 people, 30.00%
Ascites (accumulation of fluid in the abdominal cavity): 2 people, 20.00%
Diarrhea: 2 people, 20.00%
Pain: 2 people, 20.00%
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body): 2 people, 20.00%
Renal Tubular Necrosis (death of kidney tubules): 2 people, 20.00%
Abdominal Distension: 2 people, 20.00%
Urinary Tract Infection: 2 people, 20.00%

What are the existing conditions these people have? *

Urinary Tract Infection: 2 people, 20.00%
Neoplasm Malignant (cancer tumour): 2 people, 20.00%
Type 2 Diabetes: 2 people, 20.00%
Dyslipidaemia (abnormal amount of lipids): 1 person, 10.00%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 10.00%
Breakthrough Pain: 1 person, 10.00%
Candidiasis (candidiasis or thrush is a fungal infection): 1 person, 10.00%
Cardiac Disorder: 1 person, 10.00%
Cardiac Failure Congestive: 1 person, 10.00%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 1 person, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Hyzaar and have C. diff?

- Check whether C. diff is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hyzaar:

Hyzaar (16,614 reports)

C. diff treatments and more:

C. diff (13,845 reports)

How severe was C. diff and when was it recovered:

C. diff in Hyzaar

Expand to all the drugs that have ingredients of hydrochlorothiazide; losartan potassium:

C. diff and drugs with ingredients of hydrochlorothiazide; losartan potassium (11 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hyzaar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with C. diff:

C. diff (1,601 drugs)

Browse all the conditions that are associated with C. diff:

C. diff (1,776 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; losartan potassium (the active ingredients of Hyzaar) and Hyzaar (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.