Imodium and C. diff - a phase IV clinical study of FDA data

Summary:

C. diff is reported as a side effect among people who take Imodium (loperamide hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lasix, and have Multiple myeloma.

The phase IV clinical study analyzes which people have C. diff when taking Imodium. It is created by eHealthMe based on reports of 44,210 people who have side effects when taking Imodium from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,091 Imodium users. Check the latest studies of Imodium.

What is C. diff?

C. diff is found to be associated with 1,647 drugs and 1,766 conditions by eHealthMe. Check the latest studies of C. diff.

On Aug, 05, 2025

44,210 people reported to have side effects when taking Imodium.
Among them, 149 people (0.34%) have C. diff.

Among these 149 people:

How long have people been on Imodium when they have C. diff? *

What is the gender of people who have C. diff when taking Imodium? *

female: 64.58 %
male: 35.42 %

What is the age of people who have C. diff when taking Imodium? *

What are other drugs people take besides Imodium? *

What are other side effects people have besides C. diff? *

Dehydration (dryness resulting from the removal of water): 23 people, 15.44%
Nausea (feeling of having an urge to vomit): 22 people, 14.77%
Abdominal Pain: 22 people, 14.77%
Pleural Effusion (water on the lungs): 20 people, 13.42%
Pneumonia: 20 people, 13.42%
Sepsis (a severe blood infection that can lead to organ failure and death): 20 people, 13.42%
Febrile Neutropenia (fever with reduced white blood cells): 19 people, 12.75%
Abdominal Distension: 18 people, 12.08%
Drug Ineffective: 18 people, 12.08%
Chest Pain: 18 people, 12.08%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 34 people, 22.82%
Pain: 17 people, 11.41%
Depression: 17 people, 11.41%
Nausea (feeling of having an urge to vomit): 16 people, 10.74%
Bile Acid Malabsorption: 11 people, 7.38%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 10 people, 6.71%
Breast Cancer: 10 people, 6.71%
Myoclonic Epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs): 8 people, 5.37%
Nausea And Vomiting: 8 people, 5.37%
High Blood Pressure: 6 people, 4.03%

* Approximation only. Some reports may have incomplete information.

Do you take Imodium and have C. diff?

- Check whether C. diff is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Imodium:

Imodium (45,091 reports)

C. diff treatments and more:

C. diff (13,844 reports)

Common Imodium side effects:

Browse all side effects of Imodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with C. diff:

Browse all the drugs that are associated with C. diff:

C. diff (1,647 drugs)

Common conditions associated with C. diff:

Browse all the conditions that are associated with C. diff:

C. diff (1,766 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on loperamide hydrochloride (the active ingredients of Imodium) and Imodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.