Indocin and Fluid retention - a phase IV clinical study of FDA data

Summary:

Fluid retention is reported as a side effect among people who take Indocin (indomethacin), especially for people who are male, 50-59 old, have been taking the drug for 5 - 10 years also take Vioxx, and have Congestive cardiomyopathy.

The phase IV clinical study analyzes which people have Fluid retention when taking Indocin. It is created by eHealthMe based on reports of 4,328 people who have side effects when taking Indocin from the FDA, and is updated regularly.

What is Indocin?

Indocin has active ingredients of indomethacin. It is often used in gout. eHealthMe is studying from 4,559 Indocin users. Check the latest studies of Indocin.

What is Fluid retention?

Fluid retention (an abnormal accumulation of fluid in the blood) is found to be associated with 1,699 drugs and 2,448 conditions by eHealthMe. Check the latest studies of Fluid retention.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

4,328 people reported to have side effects when taking Indocin.
Among them, 30 people (0.69%) have Fluid retention.

Among these 30 people:

How long have people been on Indocin when they have Fluid retention? *

What is the gender of people who have Fluid retention when taking Indocin? *

female: 36.67 %
male: 63.33 %

What is the age of people who have Fluid retention when taking Indocin? *

What are other drugs people take besides Indocin? *

What are other side effects people have besides Fluid retention? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 50.00%
High Blood Pressure: 14 people, 46.67%
Nausea (feeling of having an urge to vomit): 14 people, 46.67%
Oedema Peripheral (superficial swelling): 14 people, 46.67%
Chest Pain: 13 people, 43.33%
Heart Attack: 13 people, 43.33%
Dyspnea (difficult or laboured breathing): 12 people, 40.00%
Hypoaesthesia (reduced sense of touch or sensation): 12 people, 40.00%
Diarrhea: 12 people, 40.00%
Abdominal Pain: 11 people, 36.67%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.67%
Congestive Cardiomyopathy (weakening of heart muscle): 2 people, 6.67%
Quit Smoking: 1 person, 3.33%
Primary Myelofibrosis (primary disorder of the bone marrow): 1 person, 3.33%
Osteoporosis (bones weak and more likely to break): 1 person, 3.33%
High Blood Pressure: 1 person, 3.33%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 1 person, 3.33%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 3.33%
Cardiac Failure Congestive: 1 person, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Indocin and have Fluid retention?

- Check whether Fluid retention is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Indocin:

Indocin (4,559 reports)

Fluid retention treatments and more:

Fluid retention (79,660 reports)

Browse all side effects of Indocin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fluid retention:

Fluid retention (1,699 drugs)

Browse all the conditions that are associated with Fluid retention:

Fluid retention (2,448 conditions)

Related publications that referenced our studies

Mantarro S, Tuccori M, Pasqualetti G, Tognini S, Montagnani S, Monzani F, Blandizzi C, "Acute portal vein thrombosis precipitated by indomethacin in a HCV-positive elderly patient", BMC geriatrics, 2012 Nov .
Mantarro S, Tuccori M, Pasqualetti G, Tognini S, Montagnani S, Monzani F, Blandizzi C, "Acute portal vein thrombosis precipitated by indomethacin in a HCV-positive elderly patient", BMC geriatrics, 2012 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on indomethacin (the active ingredients of Indocin) and Indocin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.