Invokana and Vascular rupture - a phase IV clinical study of FDA data

Summary:

Vascular rupture is reported as a side effect among people who take Invokana (canagliflozin), especially for people who are female, 50-59 old, also take Lasix, and have Asthma.

The phase IV clinical study analyzes which people have Vascular rupture when taking Invokana. It is created by eHealthMe based on reports of 29,682 people who have side effects when taking Invokana from the FDA, and is updated regularly.

What is Invokana?

Invokana has active ingredients of canagliflozin. It is often used in diabetes. eHealthMe is studying from 29,937 Invokana users. Check the latest studies of Invokana.

What is Vascular rupture?

Vascular rupture is found to be associated with 242 drugs and 296 conditions by eHealthMe. Check the latest studies of Vascular rupture.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

29,682 people reported to have side effects when taking Invokana.
Among them, 19 people (0.06%) have Vascular rupture.

Among these 19 people:

What is the gender of people who have Vascular rupture when taking Invokana? *

female: 78.95 %
male: 21.05 %

What is the age of people who have Vascular rupture when taking Invokana? *

What are other drugs people take besides Invokana? *

What are other side effects people have besides Vascular rupture? *

Fall: 16 people, 84.21%
Nosebleed (bleeding from nose): 15 people, 78.95%
Pain: 15 people, 78.95%
Dyspnea (difficult or laboured breathing): 15 people, 78.95%
Wheezing (a high-pitched whistling sound made while you breath): 15 people, 78.95%
Productive Cough: 15 people, 78.95%
Respiratory Rate Increased (excess breathing rate/min): 15 people, 78.95%
Respiratory Tract Infection: 15 people, 78.95%
Sinusitis (inflammation of sinus): 15 people, 78.95%
Heart Rate Increased: 15 people, 78.95%

What are the existing conditions these people have? *

Asthma: 15 people, 78.95%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.26%
Prostatomegaly (enlargement of the prostate): 1 person, 5.26%
High Blood Cholesterol: 1 person, 5.26%
Chest Pain: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Invokana and have Vascular rupture?

- Check whether Vascular rupture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Invokana:

Invokana (29,937 reports)

Browse all side effects of Invokana:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Vascular rupture:

Vascular rupture (242 drugs)

Browse all the conditions that are associated with Vascular rupture:

Vascular rupture (296 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on canagliflozin (the active ingredients of Invokana) and Invokana (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.