Isoniazid and Angioedema - a phase IV clinical study of FDA data

Summary:

Angioedema is reported as a side effect among people who take Isoniazid (isoniazid), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Pyrazinamide, and have Latent tuberculosis.

The phase IV clinical study analyzes which people have Angioedema when taking Isoniazid. It is created by eHealthMe based on reports of 19,852 people who have side effects when taking Isoniazid from the FDA, and is updated regularly.

What is Isoniazid?

Isoniazid has active ingredients of isoniazid. It is often used in tuberculosis. eHealthMe is studying from 20,174 Isoniazid users. Check the latest studies of Isoniazid.

What is Angioedema?

Angioedema (rapid swelling of the dermis) is found to be associated with 1,199 drugs and 2,100 conditions by eHealthMe. Check the latest studies of Angioedema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

19,852 people reported to have side effects when taking Isoniazid.
Among them, 41 people (0.21%) have Angioedema.

Among these 41 people:

How long have people been on Isoniazid when they have Angioedema? *

What is the gender of people who have Angioedema when taking Isoniazid? *

female: 80 %
male: 20 %

What is the age of people who have Angioedema when taking Isoniazid? *

What are other drugs people take besides Isoniazid? *

Pyrazinamide: 10 people, 24.39%
Rifampin: 6 people, 14.63%
Humira: 3 people, 7.32%
Ethambutol Hydrochloride: 3 people, 7.32%
Actrapid: 2 people, 4.88%
Pyridoxine: 2 people, 4.88%
Indomethacin: 2 people, 4.88%
Implanon: 2 people, 4.88%
Gliclazide: 2 people, 4.88%
Nystatin: 2 people, 4.88%

What are other side effects people have besides Angioedema? *

Urticaria (rash of round, red welts on the skin that itch intensely): 9 people, 21.95%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 8 people, 19.51%
Fever: 8 people, 19.51%
Itching: 8 people, 19.51%
Nausea And Vomiting: 6 people, 14.63%
Rash Maculo-Papular (red area on the skin that is covered with small confluent bumps): 5 people, 12.20%
Hypersensitivity: 5 people, 12.20%
Drug Rash With Eosinophilia And Systemic Symptoms (adverse drug reactions with rash): 4 people, 9.76%
Alanine Aminotransferase Increased: 4 people, 9.76%
Pneumonia: 3 people, 7.32%

What are the existing conditions these people have? *

Latent Tuberculosis (hidden tuberculosis): 3 people, 7.32%
Mastitis Bacterial (bacterial infection of breast): 2 people, 4.88%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 4.88%
Birth Control: 2 people, 4.88%
Diabetes: 2 people, 4.88%
Hereditary Angioedema (recurrent episodes of severe swelling): 2 people, 4.88%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 2 people, 4.88%
Tuberculosis Ureter (a bacterial infection of ureter by mycobacterium tuberculosis): 2 people, 4.88%
Tuberculous Pleurisy (an inflammation of lung covering plura by mycobacterium tuberculosis): 2 people, 4.88%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 2.44%

* Approximation only. Some reports may have incomplete information.

Do you take Isoniazid and have Angioedema?

- Check whether Angioedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Isoniazid:

Isoniazid (20,174 reports)

Angioedema treatments and more:

Angioedema (44,989 reports)

Browse all side effects of Isoniazid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Angioedema:

Angioedema (1,199 drugs)

Browse all the conditions that are associated with Angioedema:

Angioedema (2,100 conditions)

Related publications that referenced our studies

Ganguly, R. J., Abraham, R. R., Prasad, R., & Rao, B. C, "Hyperglycaemia induced by isoniazid preventive therapy", Journal of Family Medicine and Primary Care, 2018 Jan .
Banaga, Y., Mohmmed, K., Mustafa, H., & Barrett, J, "Angioedema 2 months after Administration of Rivaroxaban (Xarelto)", J Clin Case Rep, 2014 Jan .
Ganguly, R. J., Abraham, R. R., Prasad, R., & Rao, B. C, "Hyperglycaemia induced by isoniazid preventive therapy", Journal of Family Medicine and Primary Care, 2018 Jan .
Banaga, Y., Mohmmed, K., Mustafa, H., & Barrett, J, "Angioedema 2 months after Administration of Rivaroxaban (Xarelto)", J Clin Case Rep, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on isoniazid (the active ingredients of Isoniazid) and Isoniazid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.