Isoniazid and Coma hepatic - a phase IV clinical study of FDA data

Summary:

Coma hepatic is reported as a side effect among people who take Isoniazid (isoniazid), especially for people who are female, 20-29 old, have been taking the drug for 1 - 6 months also take Pyrazinamide, and have Hiv infection.

The phase IV clinical study analyzes which people have Coma hepatic when taking Isoniazid. It is created by eHealthMe based on reports of 19,852 people who have side effects when taking Isoniazid from the FDA, and is updated regularly.

What is Isoniazid?

Isoniazid has active ingredients of isoniazid. It is often used in tuberculosis. eHealthMe is studying from 20,174 Isoniazid users. Check the latest studies of Isoniazid.

What is Coma hepatic?

Coma hepatic (accumulation in the bloodstream of toxic substances that are normally removed by the liver leads coma) is found to be associated with 150 drugs and 409 conditions by eHealthMe. Check the latest studies of Coma hepatic.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

19,852 people reported to have side effects when taking Isoniazid.
Among them, 20 people (0.1%) have Coma hepatic.

Among these 20 people:

How long have people been on Isoniazid when they have Coma hepatic? *

What is the gender of people who have Coma hepatic when taking Isoniazid? *

female: 55.56 %
male: 44.44 %

What is the age of people who have Coma hepatic when taking Isoniazid? *

What are other drugs people take besides Isoniazid? *

What are other side effects people have besides Coma hepatic? *

Acute Hepatic Failure: 7 people, 35.00%
Hepatic Enzyme Increased: 6 people, 30.00%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 5 people, 25.00%
Rashes (redness): 5 people, 25.00%
Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 4 people, 20.00%
Drug-Induced Liver Injury (diseases of the liver that are caused by physician-prescribed medications): 4 people, 20.00%
Erythema Multiforme (a type of hypersensitivity reaction): 4 people, 20.00%
Hepatic Failure (liver failure): 4 people, 20.00%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 3 people, 15.00%
Fever: 3 people, 15.00%

What are the existing conditions these people have? *

Hiv Infection: 4 people, 20.00%
Meningitis Tuberculous (a bacterial infection of the membranes covering the brain and spinal cord (meninges)): 2 people, 10.00%
Latent Tuberculosis (hidden tuberculosis): 2 people, 10.00%
Tuberculous Pleurisy (an inflammation of lung covering plura by mycobacterium tuberculosis): 1 person, 5.00%
Tuberculosis Of Peripheral Lymph Nodes (a bacterial infection of superficial lymph node by mycobacterium tuberculosis): 1 person, 5.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.00%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 5.00%
Aspergillosis (an infection caused by a fungus called aspergillus): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Isoniazid and have Coma hepatic?

- Check whether Coma hepatic is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Isoniazid:

Isoniazid (20,174 reports)

Coma hepatic treatments and more:

Coma hepatic (1,279 reports)

Browse all side effects of Isoniazid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Coma hepatic:

Coma hepatic (150 drugs)

Browse all the conditions that are associated with Coma hepatic:

Coma hepatic (409 conditions)

Related publications that referenced our studies

Ganguly, R. J., Abraham, R. R., Prasad, R., & Rao, B. C, "Hyperglycaemia induced by isoniazid preventive therapy", Journal of Family Medicine and Primary Care, 2018 Jan .
Ganguly, R. J., Abraham, R. R., Prasad, R., & Rao, B. C, "Hyperglycaemia induced by isoniazid preventive therapy", Journal of Family Medicine and Primary Care, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on isoniazid (the active ingredients of Isoniazid) and Isoniazid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.