Isosorbide dinitrate and Hepatic necrosis - a phase IV clinical study of FDA data

Summary:

Hepatic necrosis is reported as a side effect among people who take Isosorbide dinitrate (isosorbide dinitrate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Aspirin, and have Cardiac failure congestive.

The phase IV clinical study analyzes which people have Hepatic necrosis when taking Isosorbide dinitrate. It is created by eHealthMe based on reports of 13,073 people who have side effects when taking Isosorbide dinitrate from the FDA, and is updated regularly.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

What is Hepatic necrosis?

Hepatic necrosis (large portions of liver die off due to severe liver disease) is found to be associated with 593 drugs and 743 conditions by eHealthMe. Check the latest studies of Hepatic necrosis.

On Jul, 23, 2026

13,073 people reported to have side effects when taking Isosorbide dinitrate.
Among them, 11 people (0.08%) have Hepatic necrosis.

Could Isosorbide dinitrate cause Hepatic necrosis?

Among these 11 people:

How long have people been on Isosorbide dinitrate when they have Hepatic necrosis? *

What is the gender of people who have Hepatic necrosis when taking Isosorbide dinitrate? *

female: 54.55 %
male: 45.45 %

What is the age of people who have Hepatic necrosis when taking Isosorbide dinitrate? *

What are other drugs people take besides Isosorbide dinitrate? *

Aspirin: 5 people, 45.45%
Spironolactone: 4 people, 36.36%
Furosemide: 4 people, 36.36%
Nimodipine: 2 people, 18.18%
Lescol: 2 people, 18.18%
Warfarin Sodium: 1 person, 9.09%
Digoxin: 1 person, 9.09%
Amiodarone Hydrochloride: 1 person, 9.09%
Buscopan: 1 person, 9.09%
Clopidogrel Bisulfate: 1 person, 9.09%

What are other side effects people have besides Hepatic necrosis? *

Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 4 people, 36.36%
Hepatic Fibrosis (scarring process that represents the liver's response to injury): 4 people, 36.36%
Gingival Bleeding (bleeding gums): 2 people, 18.18%
Liver Disorder (liver diseases): 2 people, 18.18%
Aspartate Aminotransferase Increased: 2 people, 18.18%
Alanine Aminotransferase Increased: 2 people, 18.18%
Lipase Increased: 1 person, 9.09%
Consciousness - Decreased: 1 person, 9.09%
Ammonia Increased: 1 person, 9.09%
Multi-Organ Failure (multisystem organ failure): 1 person, 9.09%

What are the existing conditions these people have? *

Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 4 people, 36.36%
Diabetes: 4 people, 36.36%
Cardiac Failure Congestive: 4 people, 36.36%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 18.18%
Cardiac Disorder: 2 people, 18.18%
Arrhythmias (irregular heartbeat): 2 people, 18.18%
Gout (uric acid crystals building up in the body): 1 person, 9.09%
Fungal Nail Infection: 1 person, 9.09%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Isosorbide dinitrate and have Hepatic necrosis?

- Check whether Hepatic necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Isosorbide dinitrate:

Isosorbide dinitrate (13,180 reports)

Browse all side effects of Isosorbide dinitrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic necrosis:

Hepatic necrosis (593 drugs)

Browse all the conditions that are associated with Hepatic necrosis:

Hepatic necrosis (743 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on isosorbide dinitrate (the active ingredients of Isosorbide dinitrate) and Isosorbide dinitrate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.