Jakafi and Muscle rupture - a phase IV clinical study of FDA data

Summary:

Muscle rupture is reported as a side effect among people who take Jakafi (ruxolitinib phosphate), especially for people who are female, 60+ old, also take Alvesco, and have Polycythaemia vera.

The phase IV clinical study analyzes which people have Muscle rupture when taking Jakafi. It is created by eHealthMe based on reports of 56,447 people who have side effects when taking Jakafi from the FDA, and is updated regularly.

What is Jakafi?

Jakafi has active ingredients of ruxolitinib phosphate. It is often used in primary myelofibrosis. eHealthMe is studying from 56,530 Jakafi users. Check the latest studies of Jakafi.

What is Muscle rupture?

Muscle rupture (tear in muscle) is found to be associated with 397 drugs and 508 conditions by eHealthMe. Check the latest studies of Muscle rupture.

On Jul, 14, 2026

56,447 people reported to have side effects when taking Jakafi.
Among them, 14 people (0.02%) have Muscle rupture.

Among these 14 people:

What is the gender of people who have Muscle rupture when taking Jakafi? *

female: 71.43 %
male: 28.57 %

What is the age of people who have Muscle rupture when taking Jakafi? *

What are other drugs people take besides Jakafi? *

What are other side effects people have besides Muscle rupture? *

Bone Pain: 8 people, 57.14%
Wheezing (a high-pitched whistling sound made while you breath): 7 people, 50.00%
Dyspnea (difficult or laboured breathing): 7 people, 50.00%
Weakness: 7 people, 50.00%
Hepatic Enzyme Increased: 7 people, 50.00%
Hair Loss: 7 people, 50.00%
Haemoglobin Decreased: 7 people, 50.00%
Haematocrit Abnormal: 7 people, 50.00%
Glucose Tolerance Impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 7 people, 50.00%
Gaze Palsy (disorders affecting the ability to move both eyes in the same direction): 7 people, 50.00%

What are the existing conditions these people have? *

Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 11 people, 78.57%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 7 people, 50.00%
Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 7 people, 50.00%
Muscle Disorder (muscle disease): 4 people, 28.57%
Bone Pain: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Jakafi and have Muscle rupture?

- Check whether Muscle rupture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Jakafi:

Jakafi (56,530 reports)

Muscle rupture treatments and more:

Muscle rupture (4,655 reports)

Browse all side effects of Jakafi:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle rupture:

Muscle rupture (397 drugs)

Browse all the conditions that are associated with Muscle rupture:

Muscle rupture (508 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ruxolitinib phosphate (the active ingredients of Jakafi) and Jakafi (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.