1. Home
  2. Analysis
  3. Januvia
  4. Gallbladder-operation

Januvia and Gallbladder operation - a phase IV clinical study of FDA data

Summary:

Gallbladder operation is reported as a side effect among people who take Januvia (sitagliptin phosphate), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Janumet, and have Pain.

The phase IV clinical study analyzes which people have Gallbladder operation when taking Januvia. It is created by eHealthMe based on reports of 71,642 people who have side effects when taking Januvia from the FDA, and is updated regularly.

What is Januvia?

Januvia has active ingredients of sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 72,818 Januvia users. Check the latest studies of Januvia.

What is Gallbladder operation?

Gallbladder operation is found to be associated with 340 drugs and 779 conditions by eHealthMe. Check the latest studies of Gallbladder operation.

On Aug, 10, 2026

71,642 people reported to have side effects when taking Januvia.
Among them, 28 people (0.04%) have Gallbladder operation.

Could Januvia cause Gallbladder operation?

Among these 28 people:

How long have people been on Januvia when they have Gallbladder operation? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 10 %
  • 6 - 12 months: 40 %
  • 1 - 2 years: 10 %
  • 2 - 5 years: 30 %
  • 5 - 10 years: 10 %
  • 10+ years: 0.0 %

What is the gender of people who have Gallbladder operation when taking Januvia? *

  • female: 59.26 %
  • male: 40.74 %

What is the age of people who have Gallbladder operation when taking Januvia? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 7.69 %
  • 40-49: 7.69 %
  • 50-59: 7.69 %
  • 60+: 76.92 %

What are other drugs people take besides Januvia? *

  1. Janumet: 5 people, 17.86%
  2. Lantus: 3 people, 10.71%
  3. Metoclopramide Hydrochloride: 2 people, 7.14%
  4. Nexium: 2 people, 7.14%
  5. Morphine Sulfate: 2 people, 7.14%
  6. Mirtazapine: 2 people, 7.14%
  7. Colace: 2 people, 7.14%
  8. Prilosec: 2 people, 7.14%
  9. Glimepiride: 2 people, 7.14%
  10. Exjade: 2 people, 7.14%

What are other side effects people have besides Gallbladder operation? *

  1. Pancreatic Carcinoma (pancreatic cancer): 7 people, 25.00%
  2. Renal Cyst (kidney cyst): 4 people, 14.29%
  3. Metastases To Lung (cancer spreads to lung): 4 people, 14.29%
  4. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 4 people, 14.29%
  5. Death: 4 people, 14.29%
  6. Blood Glucose Increased: 4 people, 14.29%
  7. High Blood Pressure: 4 people, 14.29%
  8. Bile Duct Obstruction (blockage in the tubes that carry bile from the liver to the gallbladder): 3 people, 10.71%
  9. Constipation: 3 people, 10.71%
  10. Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 3 people, 10.71%

What are the existing conditions these people have? *

  1. Pain: 3 people, 10.71%
  2. Hypersensitivity: 2 people, 7.14%
  3. High Blood Pressure: 2 people, 7.14%
  4. Iron Overload: 2 people, 7.14%
  5. Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 2 people, 7.14%
  6. Anaemia (lack of blood): 2 people, 7.14%
  7. Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 3.57%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 3.57%
  9. Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 3.57%
  10. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Januvia and have Gallbladder operation?

- Check whether Gallbladder operation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Januvia:

Gallbladder operation treatments and more:

How severe was Gallbladder operation and when was it recovered:

Expand to all the drugs that have ingredients of sitagliptin phosphate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Januvia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gallbladder operation:

Browse all the conditions that are associated with Gallbladder operation:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on sitagliptin phosphate (the active ingredients of Januvia) and Januvia (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.