Keytruda and Basedow's disease - a phase IV clinical study of FDA data

Summary:

Basedow's disease is reported as a side effect among people who take Keytruda (pembrolizumab), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Carboplatin, and have Lung adenocarcinoma.

The phase IV clinical study analyzes which people have Basedow's disease when taking Keytruda. It is created by eHealthMe based on reports of 57,304 people who have side effects when taking Keytruda from the FDA, and is updated regularly.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,404 Keytruda users. Check the latest studies of Keytruda.

What is Basedow's disease?

Basedow's disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones) is found to be associated with 327 drugs and 429 conditions by eHealthMe. Check the latest studies of Basedow's disease.

On Aug, 11, 2026

57,304 people reported to have side effects when taking Keytruda.
Among them, 19 people (0.03%) have Basedow's disease.

Among these 19 people:

How long have people been on Keytruda when they have Basedow's disease? *

What is the gender of people who have Basedow's disease when taking Keytruda? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Basedow's disease when taking Keytruda? *

What are other drugs people take besides Keytruda? *

Gemcitabine Hydrochloride: 3 people, 15.79%
Carboplatin: 3 people, 15.79%
Oxycodone: 2 people, 10.53%
Ondansetron: 2 people, 10.53%
Melatonin: 2 people, 10.53%
Lenvima: 2 people, 10.53%
Ativan: 2 people, 10.53%
Xgeva: 1 person, 5.26%
Pemetrexed Disodium: 1 person, 5.26%
Omeprazole: 1 person, 5.26%

What are other side effects people have besides Basedow's disease? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 31.58%
Malignant Neoplasm Progression (cancer tumour came back): 4 people, 21.05%
Drug Ineffective: 3 people, 15.79%
Diarrhea: 3 people, 15.79%
Death: 3 people, 15.79%
Myelosuppression (a decrease in the production of blood cells): 3 people, 15.79%
Fever: 2 people, 10.53%
Rashes (redness): 2 people, 10.53%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 10.53%
Thyroiditis (inflammation of thyroid gland): 2 people, 10.53%

What are the existing conditions these people have? *

Transitional Cell Carcinoma (cancer tumour inner most layer of urinary system): 2 people, 10.53%
Stress And Anxiety: 2 people, 10.53%
Bone Disorder: 2 people, 10.53%
Cardiac Disorder: 2 people, 10.53%
Dry Eyes (lack of adequate tears): 2 people, 10.53%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.53%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 2 people, 10.53%
Insomnia (sleeplessness): 2 people, 10.53%
Iron Deficiency Anaemia: 2 people, 10.53%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Keytruda and have Basedow's disease?

- Check whether Basedow's disease is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Keytruda:

Keytruda (57,404 reports)

Browse all side effects of Keytruda:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Basedow's disease:

Basedow's disease (327 drugs)

Browse all the conditions that are associated with Basedow's disease:

Basedow's disease (429 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pembrolizumab (the active ingredients of Keytruda) and Keytruda (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.