Klonopin and Adjustment disorder - a phase IV clinical study of FDA data

Summary:

Adjustment disorder is reported as a side effect among people who take Klonopin (clonazepam), especially for people who are female, 30-39 old, also take Seroquel, and have Pain.

The phase IV clinical study analyzes which people have Adjustment disorder when taking Klonopin. It is created by eHealthMe based on reports of 59,526 people who have side effects when taking Klonopin from the FDA, and is updated regularly.

What is Klonopin?

Klonopin has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 65,112 Klonopin users. Check the latest studies of Klonopin.

What is Adjustment disorder?

Adjustment disorder is found to be associated with 366 drugs and 357 conditions by eHealthMe. Check the latest studies of Adjustment disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

59,526 people reported to have side effects when taking Klonopin.
Among them, 25 people (0.04%) have Adjustment disorder.

Could Klonopin cause Adjustment disorder?

Among these 25 people:

What is the gender of people who have Adjustment disorder when taking Klonopin? *

female: 79.17 %
male: 20.83 %

What is the age of people who have Adjustment disorder when taking Klonopin? *

What are other drugs people take besides Klonopin? *

What are other side effects people have besides Adjustment disorder? *

Depression: 16 people, 64.00%
Weight Increased: 10 people, 40.00%
Insomnia (sleeplessness): 9 people, 36.00%
Pain: 8 people, 32.00%
Asthma: 8 people, 32.00%
Anaemia (lack of blood): 7 people, 28.00%
Diarrhea: 7 people, 28.00%
Osteoporosis (bones weak and more likely to break): 7 people, 28.00%
Infection: 7 people, 28.00%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 6 people, 24.00%

What are the existing conditions these people have? *

Pain: 9 people, 36.00%
Nausea (feeling of having an urge to vomit): 7 people, 28.00%
Bipolar Disorder (mood disorder): 6 people, 24.00%
Insomnia (sleeplessness): 6 people, 24.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 20.00%
Osteopenia (a condition where bone mineral density is lower than normal): 5 people, 20.00%
Osteoporosis (bones weak and more likely to break): 5 people, 20.00%
Mood Swings (an extreme or rapid change in mood): 4 people, 16.00%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 3 people, 12.00%
Nausea And Vomiting: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Klonopin and have Adjustment disorder?

- Check whether Adjustment disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Klonopin:

Klonopin (65,112 reports)

Browse all side effects of Klonopin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Adjustment disorder:

Adjustment disorder (366 drugs)

Browse all the conditions that are associated with Adjustment disorder:

Adjustment disorder (357 conditions)

Related publications that referenced our studies

McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on clonazepam (the active ingredients of Klonopin) and Klonopin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.