Krystexxa and Heart rate increased - a phase IV clinical study of FDA data

Summary:

Heart rate increased is reported as a side effect among people who take Krystexxa (pegloticase), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Benadryl, and have Gout.

The phase IV clinical study analyzes which people have Heart rate increased when taking Krystexxa. It is created by eHealthMe based on reports of 2,548 people who have side effects when taking Krystexxa from the FDA, and is updated regularly.

What is Krystexxa?

Krystexxa has active ingredients of pegloticase. eHealthMe is studying from 2,548 Krystexxa users. Check the latest studies of Krystexxa.

What is Heart rate increased?

Heart rate increased is found to be associated with 2,384 drugs and 3,212 conditions by eHealthMe. Check the latest studies of Heart rate increased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 27, 2026

2,548 people reported to have side effects when taking Krystexxa.
Among them, 31 people (1.22%) have Heart rate increased.

Could Krystexxa cause Heart rate increased?

Among these 31 people:

How long have people been on Krystexxa when they have Heart rate increased? *

What is the gender of people who have Heart rate increased when taking Krystexxa? *

female: 15.79 %
male: 84.21 %

What is the age of people who have Heart rate increased when taking Krystexxa? *

What are other drugs people take besides Krystexxa? *

What are other side effects people have besides Heart rate increased? *

High Blood Pressure: 10 people, 32.26%
Chest Pain: 9 people, 29.03%
Hypotension (abnormally low blood pressure): 8 people, 25.81%
Dyspnea (difficult or laboured breathing): 8 people, 25.81%
Nausea (feeling of having an urge to vomit): 5 people, 16.13%
Infusion Related Reaction: 5 people, 16.13%
Urticaria (rash of round, red welts on the skin that itch intensely): 5 people, 16.13%
Skin Blushing/flushing (a sudden reddening of the face, neck): 4 people, 12.90%
Gout (uric acid crystals building up in the body): 4 people, 12.90%
Blood Glucose Increased: 3 people, 9.68%

What are the existing conditions these people have? *

Gout (uric acid crystals building up in the body): 15 people, 48.39%
Diabetes: 2 people, 6.45%
Gouty Tophus (a deposit of urates in the skin and tissue around a joint or in the external ear): 1 person, 3.23%
Back Pain: 1 person, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Krystexxa and have Heart rate increased?

- Check whether Heart rate increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Krystexxa:

Krystexxa (2,548 reports)

Browse all side effects of Krystexxa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart rate increased:

Heart rate increased (2,384 drugs)

Browse all the conditions that are associated with Heart rate increased:

Heart rate increased (3,212 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pegloticase (the active ingredients of Krystexxa) and Krystexxa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.