Leflunomide and Incisional hernia - a phase IV clinical study of FDA data

Summary:

Incisional hernia is reported as a side effect among people who take Leflunomide (leflunomide), especially for people who are male, 60+ old, have been taking the drug for 5 - 10 years also take Pyrimethamine, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Incisional hernia when taking Leflunomide. It is created by eHealthMe based on reports of 81,713 people who have side effects when taking Leflunomide from the FDA, and is updated regularly.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 82,105 Leflunomide users. Check the latest studies of Leflunomide.

What is Incisional hernia?

Incisional hernia (hernia caused by an incompletely-healed surgical wound) is found to be associated with 306 drugs and 389 conditions by eHealthMe. Check the latest studies of Incisional hernia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

81,713 people reported to have side effects when taking Leflunomide.
Among them, 12 people (0.01%) have Incisional hernia.

Could Leflunomide cause Incisional hernia?

Among these 12 people:

How long have people been on Leflunomide when they have Incisional hernia? *

What is the gender of people who have Incisional hernia when taking Leflunomide? *

female: 41.67 %
male: 58.33 %

What is the age of people who have Incisional hernia when taking Leflunomide? *

What are other drugs people take besides Leflunomide? *

What are other side effects people have besides Incisional hernia? *

Enterocutaneous Fistula: 5 people, 41.67%
Wound Decomposition: 4 people, 33.33%
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon): 4 people, 33.33%
Wound Dehiscence (a surgical incision reopens either internally or externally): 3 people, 25.00%
Cholecystitis Infective (infection of gallbladder capable to infect other organs): 3 people, 25.00%
Abdominal Wall Abscess (abdominal wall infection): 3 people, 25.00%
Soft Tissue Necrosis (death of soft tissue): 3 people, 25.00%
Pneumonia: 1 person, 8.33%
Coronary Artery Occlusion (complete obstruction of blood flow in a coronary artery): 1 person, 8.33%
Sepsis (a severe blood infection that can lead to organ failure and death): 1 person, 8.33%

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 1 person, 8.33%
Pain: 1 person, 8.33%
Muscle Spasms (muscle contraction): 1 person, 8.33%
Immunodeficiency Disorders: 1 person, 8.33%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 8.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Leflunomide and have Incisional hernia?

- Check whether Incisional hernia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Leflunomide:

Leflunomide (82,105 reports)

Browse all side effects of Leflunomide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Incisional hernia:

Incisional hernia (306 drugs)

Browse all the conditions that are associated with Incisional hernia:

Incisional hernia (389 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on leflunomide (the active ingredients of Leflunomide) and Leflunomide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.