Legalon and Weakness - a phase IV clinical study of FDA data

Summary:

Weakness is reported as a side effect among people who take Legalon (milk thistle), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Harvoni, and have High blood pressure.

The phase IV clinical study analyzes which people have Weakness when taking Legalon. It is created by eHealthMe based on reports of 441 people who have side effects when taking Legalon from the FDA, and is updated regularly.

What is Legalon?

Legalon has active ingredients of milk thistle. eHealthMe is studying from 456 Legalon users. Check the latest studies of Legalon.

What is Weakness?

Weakness is found to be associated with 3,641 drugs and 6,611 conditions by eHealthMe. Check the latest studies of Weakness.

On Jul, 10, 2026

441 people reported to have side effects when taking Legalon.
Among them, 25 people (5.67%) have Weakness.

Among these 25 people:

How long have people been on Legalon when they have Weakness? *

What is the gender of people who have Weakness when taking Legalon? *

female: 64 %
male: 36 %

What is the age of people who have Weakness when taking Legalon? *

What are other drugs people take besides Legalon? *

What are other side effects people have besides Weakness? *

Gait Disturbance: 11 people, 44.00%
Disturbance In Attention: 10 people, 40.00%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 10 people, 40.00%
Hepatocellular Carcinoma (liver cancer): 9 people, 36.00%
Memory Loss: 7 people, 28.00%
Febrile Neutropenia (fever with reduced white blood cells): 4 people, 16.00%
Rhinalgia (pain in the nose): 3 people, 12.00%
Hypotension (abnormally low blood pressure): 3 people, 12.00%
Dyspnea (difficult or laboured breathing): 3 people, 12.00%
Nosebleed (bleeding from nose): 3 people, 12.00%

What are the existing conditions these people have? *

High Blood Pressure: 10 people, 40.00%
Menopausal Symptoms: 9 people, 36.00%
Chest Pain: 3 people, 12.00%
Fever: 3 people, 12.00%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 2 people, 8.00%
Acute Myeloid Leukaemia Recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent): 2 people, 8.00%
Chronic Hepatitis (long lasting inflammation of liver): 2 people, 8.00%
Liver Function Test Abnormal: 2 people, 8.00%
Multiple Myeloma (cancer of the plasma cells): 2 people, 8.00%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Legalon and have Weakness?

- Check whether Weakness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Legalon:

Legalon (456 reports)

Weakness treatments and more:

Weakness (586,876 reports)

Browse all side effects of Legalon:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Weakness:

Weakness (3,641 drugs)

Browse all the conditions that are associated with Weakness:

Weakness (6,611 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on milk thistle (the active ingredients of Legalon) and Legalon (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.