Letrozole and Multiple myeloma - a phase IV clinical study of FDA data

Summary:

Multiple myeloma is reported as a side effect among people who take Letrozole (letrozole), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Pomalyst, and have Breast cancer female.

The phase IV clinical study analyzes which people have Multiple myeloma when taking Letrozole. It is created by eHealthMe based on reports of 53,470 people who have side effects when taking Letrozole from the FDA, and is updated regularly.

What is Letrozole?

Letrozole has active ingredients of letrozole. It is often used in breast cancer. eHealthMe is studying from 54,125 Letrozole users. Check the latest studies of Letrozole.

What is Multiple myeloma?

Multiple myeloma (cancer of the plasma cells) is found to be associated with 1,107 drugs and 1,404 conditions by eHealthMe. Check the latest studies of Multiple myeloma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Aug, 26, 2026

53,470 people reported to have side effects when taking Letrozole.
Among them, 23 people (0.04%) have Multiple myeloma.

Could Letrozole cause Multiple myeloma?

Among these 23 people:

How long have people been on Letrozole when they have Multiple myeloma? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Multiple myeloma when taking Letrozole? *

  • female: 100 %
  • male: 0.0 %

What is the age of people who have Multiple myeloma when taking Letrozole? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 41.18 %
  • 60+: 58.82 %

What are other drugs people take besides Letrozole? *

  1. Pomalyst: 5 people, 21.74%
  2. Revlimid: 4 people, 17.39%
  3. Ibrance: 4 people, 17.39%
  4. Acyclovir: 2 people, 8.70%
  5. Albuterol Sulfate: 2 people, 8.70%
  6. Verzenio: 2 people, 8.70%
  7. Xpovio: 2 people, 8.70%
  8. Amlodipine: 2 people, 8.70%
  9. Anastrozole: 2 people, 8.70%
  10. Faslodex: 2 people, 8.70%

What are other side effects people have besides Multiple myeloma? *

  1. Full Blood Count Decreased: 4 people, 17.39%
  2. Anaemia (lack of blood): 3 people, 13.04%
  3. Stress And Anxiety: 3 people, 13.04%
  4. Fever: 3 people, 13.04%
  5. Second Primary Malignancy (after getting cure a cancer, a new cancer development): 3 people, 13.04%
  6. Diarrhea: 3 people, 13.04%
  7. Abdominal Distension: 2 people, 8.70%
  8. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 2 people, 8.70%
  9. Thrombocytopenia (decrease of platelets in blood): 2 people, 8.70%
  10. Fatigue (feeling of tiredness): 2 people, 8.70%

What are the existing conditions these people have? *

  1. Breast Cancer Female: 2 people, 8.70%
  2. Rashes (redness): 1 person, 4.35%
  3. Plasmacytoma (neoplasm of plasma cells (usually in bone marrow)): 1 person, 4.35%
  4. Pain: 1 person, 4.35%
  5. Neoplasm Malignant (cancer tumour): 1 person, 4.35%
  6. Constipation: 1 person, 4.35%
  7. Cancer Pain: 1 person, 4.35%
  8. Breast Cancer Recurrent: 1 person, 4.35%
  9. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Letrozole and have Multiple myeloma?

- Check whether Multiple myeloma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Letrozole:

Multiple myeloma treatments and more:

How severe was Multiple myeloma and when was it recovered:

Expand to all the drugs that have ingredients of letrozole:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Letrozole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple myeloma:

Browse all the conditions that are associated with Multiple myeloma:


How the study uses the data?

The study uses data from the FDA. It is based on letrozole (the active ingredients of Letrozole) and Letrozole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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