Leucovorin calcium and Hypercalcaemia - a phase IV clinical study of FDA data

Summary:

Hypercalcaemia is reported as a side effect among people who take Leucovorin calcium (leucovorin calcium), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Fluorouracil, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Hypercalcaemia when taking Leucovorin calcium. It is created by eHealthMe based on reports of 24,555 people who have side effects when taking Leucovorin calcium from the FDA, and is updated regularly.

What is Leucovorin calcium?

Leucovorin calcium has active ingredients of leucovorin calcium. It is often used in rheumatoid arthritis. eHealthMe is studying from 24,650 Leucovorin calcium users. Check the latest studies of Leucovorin calcium.

What is Hypercalcaemia?

Hypercalcaemia (elevated calcium (ca+) level in the blood) is found to be associated with 1,062 drugs and 1,017 conditions by eHealthMe. Check the latest studies of Hypercalcaemia.

On Jul, 16, 2026

24,555 people reported to have side effects when taking Leucovorin calcium.
Among them, 40 people (0.16%) have Hypercalcaemia.

Could Leucovorin calcium cause Hypercalcaemia?

Among these 40 people:

How long have people been on Leucovorin calcium when they have Hypercalcaemia? *

What is the gender of people who have Hypercalcaemia when taking Leucovorin calcium? *

female: 37.5 %
male: 62.5 %

What is the age of people who have Hypercalcaemia when taking Leucovorin calcium? *

What are other drugs people take besides Leucovorin calcium? *

Fluorouracil: 20 people, 50.00%
Acetaminophen: 10 people, 25.00%
Nystatin: 10 people, 25.00%
Aranesp: 10 people, 25.00%
Avastin: 9 people, 22.50%
Lasix: 9 people, 22.50%
Valacyclovir Hydrochloride: 8 people, 20.00%
Oxycontin: 8 people, 20.00%
Ambien: 8 people, 20.00%
Ampicillin Sodium: 8 people, 20.00%

What are other side effects people have besides Hypercalcaemia? *

Anaemia (lack of blood): 16 people, 40.00%
Fever: 15 people, 37.50%
Diarrhea: 14 people, 35.00%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 12 people, 30.00%
Pain: 12 people, 30.00%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 11 people, 27.50%
Nausea (feeling of having an urge to vomit): 11 people, 27.50%
Back Pain: 10 people, 25.00%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 10 people, 25.00%
Death: 10 people, 25.00%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 8 people, 20.00%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 7 people, 17.50%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 4 people, 10.00%
Chemotherapeutic Drug Level Above Therapeutic: 4 people, 10.00%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 3 people, 7.50%
Allergies: 2 people, 5.00%
Anaemia (lack of blood): 2 people, 5.00%
Colon Cancer: 2 people, 5.00%
Fever: 1 person, 2.50%
Glossodynia (a burning or painful sensation in the tongue): 1 person, 2.50%

* Approximation only. Some reports may have incomplete information.

Do you take Leucovorin calcium and have Hypercalcaemia?

- Check whether Hypercalcaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Leucovorin calcium:

Leucovorin calcium (24,650 reports)

Hypercalcaemia treatments and more:

Hypercalcaemia (18,731 reports)

Browse all side effects of Leucovorin calcium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypercalcaemia:

Hypercalcaemia (1,062 drugs)

Browse all the conditions that are associated with Hypercalcaemia:

Hypercalcaemia (1,017 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on leucovorin calcium (the active ingredients of Leucovorin calcium) and Leucovorin calcium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.