Leucovorin calcium and Nail abnormalities - a phase IV clinical study of FDA data

Summary:

Nail abnormalities is reported as a side effect among people who take Leucovorin calcium (leucovorin calcium), especially for people who are male, 30-39 old, also take Fluorouracil, and have Colon cancer.

The phase IV clinical study analyzes which people have Nail abnormalities when taking Leucovorin calcium. It is created by eHealthMe based on reports of 24,555 people who have side effects when taking Leucovorin calcium from the FDA, and is updated regularly.

What is Leucovorin calcium?

Leucovorin calcium has active ingredients of leucovorin calcium. It is often used in rheumatoid arthritis. eHealthMe is studying from 24,650 Leucovorin calcium users. Check the latest studies of Leucovorin calcium.

What is Nail abnormalities?

Nail abnormalities (abnormal nail) is found to be associated with 210 drugs and 652 conditions by eHealthMe. Check the latest studies of Nail abnormalities.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

24,555 people reported to have side effects when taking Leucovorin calcium.
Among them, 12 people (0.05%) have Nail abnormalities.

Could Leucovorin calcium cause Nail abnormalities?

Among these 12 people:

What is the gender of people who have Nail abnormalities when taking Leucovorin calcium? *

female: 0.0 %
male: 100 %

What is the age of people who have Nail abnormalities when taking Leucovorin calcium? *

What are other drugs people take besides Leucovorin calcium? *

Oxaliplatin: 8 people, 66.67%
Fluorouracil: 8 people, 66.67%
Docetaxel: 7 people, 58.33%
Prednisone: 4 people, 33.33%
Methotrexate: 4 people, 33.33%
Cyclophosphamide: 4 people, 33.33%
Etoposide: 3 people, 25.00%
Doxorubicin Hydrochloride: 2 people, 16.67%
Capecitabine: 1 person, 8.33%
Bleomycin Sulfate: 1 person, 8.33%

What are other side effects people have besides Nail abnormalities? *

Paronychia (infection in the tissues adjacent to a nail on a finger or toe): 8 people, 66.67%
Tumor Lysis Syndrome: 7 people, 58.33%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 7 people, 58.33%
Rashes (redness): 7 people, 58.33%
Skin Reaction: 5 people, 41.67%
Polyserositis (general inflammation of serous membranes, with effusion): 5 people, 41.67%
Dermatitis Bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid): 4 people, 33.33%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 3 people, 25.00%
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 2 people, 16.67%
Haematotoxicity (toxins that destroy red blood cells): 2 people, 16.67%

What are the existing conditions these people have? *

Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 1 person, 8.33%
Colon Cancer: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Leucovorin calcium and have Nail abnormalities?

- Check whether Nail abnormalities is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Leucovorin calcium:

Leucovorin calcium (24,650 reports)

Browse all side effects of Leucovorin calcium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nail abnormalities:

Nail abnormalities (210 drugs)

Browse all the conditions that are associated with Nail abnormalities:

Nail abnormalities (652 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on leucovorin calcium (the active ingredients of Leucovorin calcium) and Leucovorin calcium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.