Levaquin and Gastrointestinal perforation - a phase IV clinical study of FDA data

Summary:

Gastrointestinal perforation is reported as a side effect among people who take Levaquin (levofloxacin), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Prilosec, and have Bronchitis.

The phase IV clinical study analyzes which people have Gastrointestinal perforation when taking Levaquin. It is created by eHealthMe based on reports of 54,998 people who have side effects when taking Levaquin from the FDA, and is updated regularly.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

What is Gastrointestinal perforation?

Gastrointestinal perforation (hole in the digestive tract) is found to be associated with 928 drugs and 1,394 conditions by eHealthMe. Check the latest studies of Gastrointestinal perforation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

54,998 people reported to have side effects when taking Levaquin.
Among them, 55 people (0.1%) have Gastrointestinal perforation.

Could Levaquin cause Gastrointestinal perforation?

Among these 55 people:

How long have people been on Levaquin when they have Gastrointestinal perforation? *

What is the gender of people who have Gastrointestinal perforation when taking Levaquin? *

female: 38.18 %
male: 61.82 %

What is the age of people who have Gastrointestinal perforation when taking Levaquin? *

What are other drugs people take besides Levaquin? *

What are other side effects people have besides Gastrointestinal perforation? *

Abdominal Pain: 31 people, 56.36%
Nausea (feeling of having an urge to vomit): 27 people, 49.09%
Sepsis (a severe blood infection that can lead to organ failure and death): 25 people, 45.45%
Acute Kidney Failure: 24 people, 43.64%
Nausea And Vomiting: 24 people, 43.64%
Hypotension (abnormally low blood pressure): 24 people, 43.64%
Anaemia (lack of blood): 21 people, 38.18%
Pain: 19 people, 34.55%
Fall: 17 people, 30.91%
Stress And Anxiety: 17 people, 30.91%

What are the existing conditions these people have? *

Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 12 people, 21.82%
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 10 people, 18.18%
Hypotension (abnormally low blood pressure): 10 people, 18.18%
Metastases To Bone (cancer spreads to bone): 10 people, 18.18%
Renal Cell Carcinoma (a kidney cancer): 8 people, 14.55%
Pain: 7 people, 12.73%
Depression: 4 people, 7.27%
Urinary Tract Infection: 4 people, 7.27%
High Blood Pressure: 3 people, 5.45%
Stress And Anxiety: 3 people, 5.45%

* Approximation only. Some reports may have incomplete information.

Do you take Levaquin and have Gastrointestinal perforation?

- Check whether Gastrointestinal perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levaquin:

Levaquin (56,638 reports)

Browse all side effects of Levaquin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gastrointestinal perforation:

Gastrointestinal perforation (928 drugs)

Browse all the conditions that are associated with Gastrointestinal perforation:

Gastrointestinal perforation (1,394 conditions)

Related publications that referenced our studies

Bhuvan KC, ALrasheedy AA, Ibrahim MI, "A case report from Nepalese community pharmacy on levofloxacin induced severe abdominal pain", Saudi Pharmaceutical Journal, 2013 Jul .
MITTAL V, ARCHANA D, GUPTA A, SRIVASTAV U, CHANDRA V, SAXENA A, AGRAWAL P, "Aphasia: a Rarest Complication with a Well Known Drug Levofloxacin", Medical Science, 2013 Jan .
Bhuvan KC, ALrasheedy AA, Ibrahim MI, "A case report from Nepalese community pharmacy on levofloxacin induced severe abdominal pain", Saudi Pharmaceutical Journal, 2013 Jul .
MITTAL V, ARCHANA D, GUPTA A, SRIVASTAV U, CHANDRA V, SAXENA A, AGRAWAL P, "Aphasia: a Rarest Complication with a Well Known Drug Levofloxacin", Medical Science, 2013 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on levofloxacin (the active ingredients of Levaquin) and Levaquin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.