Levothroid and Anhedonia - a phase IV clinical study of FDA data

Summary:

Anhedonia is reported as a side effect among people who take Levothroid (levothyroxine sodium), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Imodium, and have Nuclear magnetic resonance imaging abdominal.

The phase IV clinical study analyzes which people have Anhedonia when taking Levothroid. It is created by eHealthMe based on reports of 8,088 people who have side effects when taking Levothroid from the FDA, and is updated regularly.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

What is Anhedonia?

Anhedonia (inability to experience pleasure from activities usually found enjoyable) is found to be associated with 1,511 drugs and 1,274 conditions by eHealthMe. Check the latest studies of Anhedonia.

On Jul, 12, 2026

8,088 people reported to have side effects when taking Levothroid.
Among them, 27 people (0.33%) have Anhedonia.

Among these 27 people:

How long have people been on Levothroid when they have Anhedonia? *

What is the gender of people who have Anhedonia when taking Levothroid? *

female: 62.96 %
male: 37.04 %

What is the age of people who have Anhedonia when taking Levothroid? *

What are other drugs people take besides Levothroid? *

What are other side effects people have besides Anhedonia? *

Pain: 20 people, 74.07%
Stress And Anxiety: 18 people, 66.67%
Emotional Distress: 16 people, 59.26%
Depression: 13 people, 48.15%
Rashes (redness): 12 people, 44.44%
Injury: 10 people, 37.04%
General Physical Health Deterioration (weak health status): 10 people, 37.04%
Skin Ulcer: 10 people, 37.04%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 8 people, 29.63%
Neuropathic Arthropathy (a progressive destruction of bone and joints): 6 people, 22.22%

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Abdominal: 6 people, 22.22%
Hiv Infection: 4 people, 14.81%
Nuclear Magnetic Resonance Imaging Brain: 3 people, 11.11%
Pain: 3 people, 11.11%
Depression: 3 people, 11.11%
Hypersensitivity: 2 people, 7.41%
Infection: 2 people, 7.41%
Erection Problems: 2 people, 7.41%
Nausea (feeling of having an urge to vomit): 2 people, 7.41%
Urinary Tract Infection: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Levothroid and have Anhedonia?

- Check whether Anhedonia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levothroid:

Levothroid (8,974 reports)

Anhedonia treatments and more:

Anhedonia (51,943 reports)

Browse all side effects of Levothroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anhedonia:

Anhedonia (1,511 drugs)

Browse all the conditions that are associated with Anhedonia:

Anhedonia (1,274 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Levothroid) and Levothroid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.