Levothroid and Irritability - a phase IV clinical study of FDA data

Summary:

Irritability is reported as a side effect among people who take Levothroid (levothyroxine sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Klonopin, and have Bipolar disorder.

The phase IV clinical study analyzes which people have Irritability when taking Levothroid. It is created by eHealthMe based on reports of 8,088 people who have side effects when taking Levothroid from the FDA, and is updated regularly.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,973 Levothroid users. Check the latest studies of Levothroid.

What is Irritability?

Irritability is found to be associated with 1,714 drugs and 2,442 conditions by eHealthMe. Check the latest studies of Irritability.

On Jan, 11, 2026

8,088 people reported to have side effects when taking Levothroid.
Among them, 21 people (0.26%) have Irritability.

Among these 21 people:

How long have people been on Levothroid when they have Irritability? *

What is the gender of people who have Irritability when taking Levothroid? *

female: 80.95 %
male: 19.05 %

What is the age of people who have Irritability when taking Levothroid? *

What are other drugs people take besides Levothroid? *

What are other side effects people have besides Irritability? *

Fatigue (feeling of tiredness): 6 people, 28.57%
Nausea (feeling of having an urge to vomit): 6 people, 28.57%
Stress And Anxiety: 5 people, 23.81%
Dizziness: 5 people, 23.81%
Weight Increased: 4 people, 19.05%
Insomnia (sleeplessness): 4 people, 19.05%
High Blood Pressure: 3 people, 14.29%
Hyperhidrosis (abnormally increased sweating): 3 people, 14.29%
Itching: 3 people, 14.29%
Diarrhea: 3 people, 14.29%

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 2 people, 9.52%
Type 2 Diabetes: 1 person, 4.76%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 4.76%
Pain: 1 person, 4.76%
Macular Degeneration (painless eye condition that leads to the gradual loss of central vision): 1 person, 4.76%
Lung Neoplasm Malignant (cancer tumour of lung): 1 person, 4.76%
Ill-Defined Disorder: 1 person, 4.76%
Hepatitis C: 1 person, 4.76%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 4.76%
Drug Dependence: 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Levothroid and have Irritability?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levothroid:

Levothroid (8,973 reports)

Irritability treatments and more:

Irritability (71,612 reports)

Browse all side effects of Levothroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Irritability:

Irritability (1,714 drugs)

Browse all the conditions that are associated with Irritability:

Irritability (2,442 conditions)

Drugs similar to Levothroid and Irritability :

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Levothroid) and Levothroid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.