Levothyroxine sodium and Aphthous stomatitis - a phase IV clinical study of FDA data

Summary:

Aphthous stomatitis is reported as a side effect among people who take Levothyroxine sodium (levothyroxine sodium), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Aspirin, and have Rosacea.

The phase IV clinical study analyzes which people have Aphthous stomatitis when taking Levothyroxine sodium. It is created by eHealthMe based on reports of 122,907 people who have side effects when taking Levothyroxine sodium from the FDA, and is updated regularly.

What is Levothyroxine sodium?

Levothyroxine sodium has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 129,812 Levothyroxine sodium users. Check the latest studies of Levothyroxine sodium.

What is Aphthous stomatitis?

Aphthous stomatitis (mouth ulcer) is found to be associated with 433 drugs and 811 conditions by eHealthMe. Check the latest studies of Aphthous stomatitis.

On Jul, 06, 2026

122,907 people reported to have side effects when taking Levothyroxine sodium.
Among them, 52 people (0.04%) have Aphthous stomatitis.

Could Levothyroxine sodium cause Aphthous stomatitis?

Among these 52 people:

How long have people been on Levothyroxine sodium when they have Aphthous stomatitis? *

What is the gender of people who have Aphthous stomatitis when taking Levothyroxine sodium? *

female: 75.51 %
male: 24.49 %

What is the age of people who have Aphthous stomatitis when taking Levothyroxine sodium? *

What are other drugs people take besides Levothyroxine sodium? *

What are other side effects people have besides Aphthous stomatitis? *

Headache (pain in head): 17 people, 32.69%
Fibromyalgia (a long-term condition which causes pain all over the body): 11 people, 21.15%
Depression: 11 people, 21.15%
Oral Herpes (viral infection of mouth): 10 people, 19.23%
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 9 people, 17.31%
Small Intestinal Obstruction (blockage in small intestine): 9 people, 17.31%
Fever: 9 people, 17.31%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 9 people, 17.31%
Inflammatory Bowel Disease: 9 people, 17.31%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 9 people, 17.31%

What are the existing conditions these people have? *

Acne (skin problems that cause pimples): 10 people, 19.23%
Rosacea (a skin condition that causes facial redness): 10 people, 19.23%
Birth Control: 6 people, 11.54%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 9.62%
Pain: 5 people, 9.62%
Hepatitis C: 4 people, 7.69%
High Blood Pressure: 4 people, 7.69%
Bipolar Disorder (mood disorder): 3 people, 5.77%
Swelling: 2 people, 3.85%
Multiple Myeloma (cancer of the plasma cells): 2 people, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Levothyroxine sodium and have Aphthous stomatitis?

- Check whether Aphthous stomatitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levothyroxine sodium:

Levothyroxine sodium (129,812 reports)

Browse all side effects of Levothyroxine sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aphthous stomatitis:

Aphthous stomatitis (433 drugs)

Browse all the conditions that are associated with Aphthous stomatitis:

Aphthous stomatitis (811 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Levothyroxine sodium) and Levothyroxine sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.