Levothyroxine sodium and Hepatojugular reflux - a phase IV clinical study of FDA data

Summary:

Hepatojugular reflux is reported as a side effect among people who take Levothyroxine sodium (levothyroxine sodium), especially for people who are male, 40-49 old, also take Spironolactone, and have Depression.

The phase IV clinical study analyzes which people have Hepatojugular reflux when taking Levothyroxine sodium. It is created by eHealthMe based on reports of 122,907 people who have side effects when taking Levothyroxine sodium from the FDA, and is updated regularly.

What is Levothyroxine sodium?

Levothyroxine sodium has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 129,814 Levothyroxine sodium users. Check the latest studies of Levothyroxine sodium.

What is Hepatojugular reflux?

Hepatojugular reflux (a venous reflux occurring in congestive heart failure) is found to be associated with 69 drugs and 114 conditions by eHealthMe. Check the latest studies of Hepatojugular reflux.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

122,907 people reported to have side effects when taking Levothyroxine sodium.
Among them, 16 people (0.01%) have Hepatojugular reflux.

Could Levothyroxine sodium cause Hepatojugular reflux?

Among these 16 people:

What is the gender of people who have Hepatojugular reflux when taking Levothyroxine sodium? *

female: 33.33 %
male: 66.67 %

What is the age of people who have Hepatojugular reflux when taking Levothyroxine sodium? *

What are other drugs people take besides Levothyroxine sodium? *

What are other side effects people have besides Hepatojugular reflux? *

Mitral Valve Incompetence (inefficient heart valve): 10 people, 62.50%
Hypotension (abnormally low blood pressure): 8 people, 50.00%
Cardiac Failure: 7 people, 43.75%
Acute Kidney Failure: 7 people, 43.75%
Cholecystitis Acute (rapid infection of gallbladder): 6 people, 37.50%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 37.50%
Cardiac Failure Congestive: 5 people, 31.25%
Brain Natriuretic Peptide Increased: 5 people, 31.25%
Jugular Vein Distension (overloaded jugular vein): 5 people, 31.25%
Atrioventricular Block First Degree (heart block first degree): 5 people, 31.25%

What are the existing conditions these people have? *

Depression: 4 people, 25.00%
Diabetes: 3 people, 18.75%
Renal Cancer Metastatic (cancer of kidney spreads to other part): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Levothyroxine sodium and have Hepatojugular reflux?

- Check whether Hepatojugular reflux is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levothyroxine sodium:

Levothyroxine sodium (129,814 reports)

Browse all side effects of Levothyroxine sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatojugular reflux:

Hepatojugular reflux (69 drugs)

Browse all the conditions that are associated with Hepatojugular reflux:

Hepatojugular reflux (114 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Levothyroxine sodium) and Levothyroxine sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.