Levothyroxine sodium and Major depression - a phase IV clinical study of FDA data

Summary:

Major depression is reported as a side effect among people who take Levothyroxine sodium (levothyroxine sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Valproate Sodium, and have Diarrhea.

The phase IV clinical study analyzes which people have Major depression when taking Levothyroxine sodium. It is created by eHealthMe based on reports of 122,907 people who have side effects when taking Levothyroxine sodium from the FDA, and is updated regularly.

What is Levothyroxine sodium?

Levothyroxine sodium has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 129,812 Levothyroxine sodium users. Check the latest studies of Levothyroxine sodium.

What is Major depression?

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings) is found to be associated with 803 drugs and 1,476 conditions by eHealthMe. Check the latest studies of Major depression.

On Jul, 20, 2026

122,907 people reported to have side effects when taking Levothyroxine sodium.
Among them, 77 people (0.06%) have Major depression.

Could Levothyroxine sodium cause Major depression?

Among these 77 people:

How long have people been on Levothyroxine sodium when they have Major depression? *

What is the gender of people who have Major depression when taking Levothyroxine sodium? *

female: 84.42 %
male: 15.58 %

What is the age of people who have Major depression when taking Levothyroxine sodium? *

What are other drugs people take besides Levothyroxine sodium? *

Valproate Sodium: 15 people, 19.48%
Magnesium Sulfate: 14 people, 18.18%
Potassium Aspartate: 13 people, 16.88%
Lorazepam: 12 people, 15.58%
Docetaxel: 12 people, 15.58%
Cetirizine Hydrochloride: 11 people, 14.29%
Letrozole: 11 people, 14.29%
Telmisartan: 11 people, 14.29%
Magnesium: 11 people, 14.29%
Nexium: 9 people, 11.69%

What are other side effects people have besides Major depression? *

Stress And Anxiety: 21 people, 27.27%
Fatigue (feeling of tiredness): 13 people, 16.88%
Fall: 13 people, 16.88%
Suicidal Ideation: 13 people, 16.88%
High Blood Pressure: 11 people, 14.29%
Drug Ineffective: 11 people, 14.29%
Muscle Spasms (muscle contraction): 9 people, 11.69%
Weakness: 9 people, 11.69%
Memory Loss: 8 people, 10.39%
Pain In Extremity: 8 people, 10.39%

What are the existing conditions these people have? *

Diarrhea: 13 people, 16.88%
Hypokalemia (low potassium): 12 people, 15.58%
Itching: 12 people, 15.58%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 12 people, 15.58%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 12 people, 15.58%
Depression: 12 people, 15.58%
Breast Cancer Metastatic: 10 people, 12.99%
High Blood Pressure: 8 people, 10.39%
Osteopenia (a condition where bone mineral density is lower than normal): 7 people, 9.09%
Pain: 5 people, 6.49%

* Approximation only. Some reports may have incomplete information.

Do you take Levothyroxine sodium and have Major depression?

- Check whether Major depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levothyroxine sodium:

Levothyroxine sodium (129,812 reports)

Major depression treatments and more:

Major depression (44,979 reports)

Browse all side effects of Levothyroxine sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Major depression:

Major depression (803 drugs)

Browse all the conditions that are associated with Major depression:

Major depression (1,476 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Levothyroxine sodium) and Levothyroxine sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.