Levothyroxine sodium and Nephrocalcinosis - a phase IV clinical study of FDA data

Summary:

Nephrocalcinosis is reported as a side effect among people who take Levothyroxine sodium (levothyroxine sodium), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Hydrochlorothiazide, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Nephrocalcinosis when taking Levothyroxine sodium. It is created by eHealthMe based on reports of 122,907 people who have side effects when taking Levothyroxine sodium from the FDA, and is updated regularly.

What is Levothyroxine sodium?

Levothyroxine sodium has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 129,814 Levothyroxine sodium users. Check the latest studies of Levothyroxine sodium.

What is Nephrocalcinosis?

Nephrocalcinosis (a condition in which calcium levels in the kidneys are increased) is found to be associated with 154 drugs and 257 conditions by eHealthMe. Check the latest studies of Nephrocalcinosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

122,907 people reported to have side effects when taking Levothyroxine sodium.
Among them, 26 people (0.02%) have Nephrocalcinosis.

Could Levothyroxine sodium cause Nephrocalcinosis?

Among these 26 people:

How long have people been on Levothyroxine sodium when they have Nephrocalcinosis? *

What is the gender of people who have Nephrocalcinosis when taking Levothyroxine sodium? *

female: 76.92 %
male: 23.08 %

What is the age of people who have Nephrocalcinosis when taking Levothyroxine sodium? *

What are other drugs people take besides Levothyroxine sodium? *

What are other side effects people have besides Nephrocalcinosis? *

Acute Kidney Failure: 9 people, 34.62%
Interstitial Nephritis (inflammation of the kidney): 7 people, 26.92%
Constipation: 7 people, 26.92%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 6 people, 23.08%
Nausea (feeling of having an urge to vomit): 5 people, 19.23%
Anaemia (lack of blood): 5 people, 19.23%
Fatigue (feeling of tiredness): 4 people, 15.38%
Hypophagia (reduced food intake): 4 people, 15.38%
Weight Decreased: 4 people, 15.38%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 4 people, 15.38%

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 19.23%
Hypoparathyroidism (inadequate secretion of parathyroid hormone resulting in abnormally low levels of calcium in the blood): 4 people, 15.38%
Pain: 3 people, 11.54%
Gastric Disorder (disease of stomach): 3 people, 11.54%
Joint Pain: 2 people, 7.69%
Gastric Ph Decreased: 2 people, 7.69%
Hypersensitivity: 2 people, 7.69%
Intraocular Pressure Increased: 2 people, 7.69%
Abdominal Pain Upper: 2 people, 7.69%
Constipation: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Levothyroxine sodium and have Nephrocalcinosis?

- Check whether Nephrocalcinosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levothyroxine sodium:

Levothyroxine sodium (129,814 reports)

Browse all side effects of Levothyroxine sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nephrocalcinosis:

Nephrocalcinosis (154 drugs)

Browse all the conditions that are associated with Nephrocalcinosis:

Nephrocalcinosis (257 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Levothyroxine sodium) and Levothyroxine sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.