Levothyroxine sodium and Oedema - a phase IV clinical study of FDA data

Summary:

Oedema is reported as a side effect among people who take Levothyroxine sodium (levothyroxine sodium), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Acetaminophen, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Oedema when taking Levothyroxine sodium. It is created by eHealthMe based on reports of 122,907 people who have side effects when taking Levothyroxine sodium from the FDA, and is updated regularly.

What is Levothyroxine sodium?

Levothyroxine sodium has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 129,790 Levothyroxine sodium users. Check the latest studies of Levothyroxine sodium.

What is Oedema?

Oedema (fluid collection in tissue) is found to be associated with 2,276 drugs and 2,303 conditions by eHealthMe. Check the latest studies of Oedema.



On Oct, 23, 2025

122,907 people reported to have side effects when taking Levothyroxine sodium.
Among them, 1,187 people (0.97%) have Oedema.

Could Levothyroxine sodium cause Oedema?

Among these 1,187 people:

How long have people been on Levothyroxine sodium when they have Oedema? *

  • < 1 month: 43.75 %
  • 1 - 6 months: 50.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 6.25 %

What is the gender of people who have Oedema when taking Levothyroxine sodium? *

  • female: 82.98 %
  • male: 17.02 %

What is the age of people who have Oedema when taking Levothyroxine sodium? *

  • 0-1: 0.31 %
  • 2-9: 0.1 %
  • 10-19: 0.72 %
  • 20-29: 1.75 %
  • 30-39: 3.51 %
  • 40-49: 28.66 %
  • 50-59: 18.66 %
  • 60+: 46.29 %

What are other drugs people take besides Levothyroxine sodium? *

  1. Acetaminophen: 384 people, 32.35%
  2. Prednisone: 378 people, 31.84%
  3. Humira: 341 people, 28.73%
  4. Folic Acid: 336 people, 28.31%
  5. Enbrel: 330 people, 27.80%
  6. Fosamax: 327 people, 27.55%
  7. Magnesium: 327 people, 27.55%
  8. Lisinopril: 325 people, 27.38%
  9. Actemra: 322 people, 27.13%
  10. Arava: 319 people, 26.87%

What are other side effects people have besides Oedema? *

  1. Pain: 433 people, 36.48%
  2. Fatigue (feeling of tiredness): 423 people, 35.64%
  3. Headache (pain in head): 393 people, 33.11%
  4. Rashes (redness): 382 people, 32.18%
  5. High Blood Pressure: 370 people, 31.17%
  6. Nausea And Vomiting: 367 people, 30.92%
  7. Joint Pain: 364 people, 30.67%
  8. Weakness: 363 people, 30.58%
  9. Diarrhea: 347 people, 29.23%
  10. Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 333 people, 28.05%

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 362 people, 30.50%
  2. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 303 people, 25.53%
  3. Psoriasis (immune-mediated disease that affects the skin): 177 people, 14.91%
  4. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 125 people, 10.53%
  5. Arthritis (form of joint disorder that involves inflammation of one or more joints): 93 people, 7.83%
  6. Stress And Anxiety: 89 people, 7.50%
  7. Pain: 88 people, 7.41%
  8. High Blood Pressure: 87 people, 7.33%
  9. Pemphigus (any of several acute or chronic skin diseases characterized by groups of itching blisters): 71 people, 5.98%
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 69 people, 5.81%

* Approximation only. Some reports may have incomplete information.

Do you take Levothyroxine sodium and have Oedema?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levothyroxine sodium:

Oedema treatments and more:

How severe was Oedema and when was it recovered:

Expand to all the drugs that have ingredients of levothyroxine sodium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Levothyroxine sodium side effects:

Browse all side effects of Levothyroxine sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Oedema:

Browse all the drugs that are associated with Oedema:

Common conditions associated with Oedema:

Browse all the conditions that are associated with Oedema:

Drugs similar to Levothyroxine sodium and Oedema :


How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Levothyroxine sodium) and Levothyroxine sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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