Levoxyl and Generalised oedema - a phase IV clinical study of FDA data

Summary:

Generalised oedema is reported as a side effect among people who take Levoxyl (levothyroxine sodium), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Lasix, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Generalised oedema when taking Levoxyl. It is created by eHealthMe based on reports of 23,566 people who have side effects when taking Levoxyl from the FDA, and is updated regularly.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

What is Generalised oedema?

Generalised oedema (swelling all over the body) is found to be associated with 1,088 drugs and 1,406 conditions by eHealthMe. Check the latest studies of Generalised oedema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

23,566 people reported to have side effects when taking Levoxyl.
Among them, 22 people (0.09%) have Generalised oedema.

Among these 22 people:

How long have people been on Levoxyl when they have Generalised oedema? *

What is the gender of people who have Generalised oedema when taking Levoxyl? *

female: 90.48 %
male: 9.52 %

What is the age of people who have Generalised oedema when taking Levoxyl? *

What are other drugs people take besides Levoxyl? *

What are other side effects people have besides Generalised oedema? *

Weight Increased: 10 people, 45.45%
Pain: 6 people, 27.27%
High Blood Pressure: 5 people, 22.73%
Fatigue (feeling of tiredness): 5 people, 22.73%
Fluid Retention (an abnormal accumulation of fluid in the blood): 5 people, 22.73%
Dyspnea (difficult or laboured breathing): 5 people, 22.73%
Weakness: 5 people, 22.73%
Pleural Effusion (water on the lungs): 4 people, 18.18%
Pain In Extremity: 4 people, 18.18%
Depression: 4 people, 18.18%

What are the existing conditions these people have? *

High Blood Cholesterol: 3 people, 13.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.64%
Type 2 Diabetes: 2 people, 9.09%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 9.09%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 9.09%
Pain In Extremity: 2 people, 9.09%
High Blood Pressure: 2 people, 9.09%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 4.55%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 4.55%
Bacterial Infection: 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Levoxyl and have Generalised oedema?

- Check whether Generalised oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levoxyl:

Levoxyl (25,178 reports)

Browse all side effects of Levoxyl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Generalised oedema:

Generalised oedema (1,088 drugs)

Browse all the conditions that are associated with Generalised oedema:

Generalised oedema (1,406 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Levoxyl) and Levoxyl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.