Linzess and Thyroid function test abnormal - a phase IV clinical study of FDA data

Summary:

Thyroid function test abnormal is reported as a side effect among people who take Linzess (linaclotide), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Synthroid, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Thyroid function test abnormal when taking Linzess. It is created by eHealthMe based on reports of 23,558 people who have side effects when taking Linzess from the FDA, and is updated regularly.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,081 Linzess users. Check the latest studies of Linzess.

What is Thyroid function test abnormal?

Thyroid function test abnormal is found to be associated with 1,707 drugs and 1,582 conditions by eHealthMe. Check the latest studies of Thyroid function test abnormal.

On Nov, 18, 2025

23,558 people reported to have side effects when taking Linzess.
Among them, 37 people (0.16%) have Thyroid function test abnormal.

Could Linzess cause Thyroid function test abnormal?

Among these 37 people:

How long have people been on Linzess when they have Thyroid function test abnormal? *

What is the gender of people who have Thyroid function test abnormal when taking Linzess? *

female: 91.18 %
male: 8.82 %

What is the age of people who have Thyroid function test abnormal when taking Linzess? *

What are other drugs people take besides Linzess? *

What are other side effects people have besides Thyroid function test abnormal? *

Malaise (a feeling of general discomfort or uneasiness): 9 people, 24.32%
Fatigue (feeling of tiredness): 9 people, 24.32%
Weight Decreased: 8 people, 21.62%
Memory Loss: 8 people, 21.62%
Dyspnea (difficult or laboured breathing): 7 people, 18.92%
Pain: 7 people, 18.92%
Chills (felling of cold): 7 people, 18.92%
Drowsiness: 7 people, 18.92%
High Blood Pressure: 6 people, 16.22%
Nausea And Vomiting: 6 people, 16.22%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 13.51%
Immunodeficiency Common Variable: 5 people, 13.51%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 10.81%
Gait Disturbance: 3 people, 8.11%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 5.41%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 5.41%
Stress And Anxiety: 2 people, 5.41%
Immunodeficiency: 2 people, 5.41%
Immune System Disorder: 2 people, 5.41%
Delusion (a false belief or opinion): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Linzess and have Thyroid function test abnormal?

- Check whether Thyroid function test abnormal is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Linzess:

Linzess (24,081 reports)

Browse all side effects of Linzess:

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Browse all the drugs that are associated with Thyroid function test abnormal:

Thyroid function test abnormal (1,707 drugs)

Browse all the conditions that are associated with Thyroid function test abnormal:

Thyroid function test abnormal (1,582 conditions)

Drugs similar to Linzess and Thyroid function test abnormal :

How the study uses the data?

The study uses data from the FDA. It is based on linaclotide (the active ingredients of Linzess) and Linzess (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.