Locoid and Interstitial nephritis - a phase IV clinical study of FDA data

Summary:

Interstitial nephritis is reported as a side effect among people who take Locoid (hydrocortisone butyrate), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Kayexalate, and have Diabetes.

The phase IV clinical study analyzes which people have Interstitial nephritis when taking Locoid. It is created by eHealthMe based on reports of 1,990 people who have side effects when taking Locoid from the FDA, and is updated regularly.

What is Locoid?

Locoid has active ingredients of hydrocortisone butyrate. eHealthMe is studying from 1,996 Locoid users. Check the latest studies of Locoid.

What is Interstitial nephritis?

Interstitial nephritis (inflammation of the kidney) is found to be associated with 1,089 drugs and 1,567 conditions by eHealthMe. Check the latest studies of Interstitial nephritis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

1,990 people reported to have side effects when taking Locoid.
Among them, 11 people (0.55%) have Interstitial nephritis.

Could Locoid cause Interstitial nephritis?

Among these 11 people:

How long have people been on Locoid when they have Interstitial nephritis? *

What is the gender of people who have Interstitial nephritis when taking Locoid? *

female: 0.0 %
male: 100 %

What is the age of people who have Interstitial nephritis when taking Locoid? *

What are other drugs people take besides Locoid? *

What are other side effects people have besides Interstitial nephritis? *

Renal Impairment (severely reduced kidney function): 6 people, 54.55%
Dizziness: 6 people, 54.55%
Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 4 people, 36.36%
Nephropathy (damage to or disease of a kidney): 4 people, 36.36%
Febrile Neutropenia (fever with reduced white blood cells): 4 people, 36.36%
Amylase Increased: 4 people, 36.36%
Cataract (clouding of the lens inside the eye): 3 people, 27.27%
Sepsis (a severe blood infection that can lead to organ failure and death): 2 people, 18.18%
Hydrocephalus (water on the brain): 2 people, 18.18%
Urticaria (rash of round, red welts on the skin that itch intensely): 1 person, 9.09%

What are the existing conditions these people have? *

Diabetes: 7 people, 63.64%
Constipation: 4 people, 36.36%
Cancer Pain: 4 people, 36.36%
Pain: 4 people, 36.36%
Non-Small Cell Lung Cancer Stage Iv: 4 people, 36.36%
Lung Neoplasm Malignant (cancer tumour of lung): 4 people, 36.36%
Infection: 4 people, 36.36%
High Blood Pressure: 4 people, 36.36%
Rashes (redness): 4 people, 36.36%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 4 people, 36.36%

* Approximation only. Some reports may have incomplete information.

Do you take Locoid and have Interstitial nephritis?

- Check whether Interstitial nephritis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Locoid:

Locoid (1,996 reports)

Browse all side effects of Locoid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Interstitial nephritis:

Interstitial nephritis (1,089 drugs)

Browse all the conditions that are associated with Interstitial nephritis:

Interstitial nephritis (1,567 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrocortisone butyrate (the active ingredients of Locoid) and Locoid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.