Lomotil and Rickets - a phase IV clinical study of FDA data

Summary:

Rickets is reported as a side effect among people who take Lomotil (atropine sulfate; diphenoxylate hydrochloride), especially for people who are female, 60+ old, also take Prilosec, and have High blood pressure.

The phase IV clinical study analyzes which people have Rickets when taking Lomotil. It is created by eHealthMe based on reports of 18,891 people who have side effects when taking Lomotil from the FDA, and is updated regularly.

What is Lomotil?

Lomotil has active ingredients of atropine sulfate; diphenoxylate hydrochloride. It is often used in diarrhea. eHealthMe is studying from 19,184 Lomotil users. Check the latest studies of Lomotil.

What is Rickets?

Rickets (softening of bones) is found to be associated with 1,087 drugs and 1,459 conditions by eHealthMe. Check the latest studies of Rickets.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 05, 2026

18,891 people reported to have side effects when taking Lomotil.
Among them, 57 people (0.3%) have Rickets.

Among these 57 people:

What is the gender of people who have Rickets when taking Lomotil? *

female: 80.77 %
male: 19.23 %

What is the age of people who have Rickets when taking Lomotil? *

What are other drugs people take besides Lomotil? *

What are other side effects people have besides Rickets? *

Depression: 20 people, 35.09%
Stress And Anxiety: 17 people, 29.82%
Urinary Tract Infection: 14 people, 24.56%
Nausea (feeling of having an urge to vomit): 14 people, 24.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 24.56%
Pain: 14 people, 24.56%
Nausea And Vomiting: 13 people, 22.81%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 11 people, 19.30%
Osteopenia (a condition where bone mineral density is lower than normal): 11 people, 19.30%
Asthma: 11 people, 19.30%

What are the existing conditions these people have? *

High Blood Pressure: 7 people, 12.28%
Pain: 6 people, 10.53%
Nausea (feeling of having an urge to vomit): 5 people, 8.77%
Depression: 4 people, 7.02%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 7.02%
Osteoporosis (bones weak and more likely to break): 4 people, 7.02%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 7.02%
Carcinoid Syndrome (syndrome includes flushing and diarrhoea, and, less frequently, heart failure and bronchoconstriction): 3 people, 5.26%
Ovarian Cancer (cancer of ovary): 3 people, 5.26%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Lomotil and have Rickets?

- Check whether Rickets is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lomotil:

Lomotil (19,184 reports)

Rickets treatments and more:

Rickets (30,776 reports)

How severe was Rickets and when was it recovered:

Rickets in Lomotil

Expand to all the drugs that have ingredients of atropine sulfate; diphenoxylate hydrochloride:

Rickets and drugs with ingredients of atropine sulfate; diphenoxylate hydrochloride (63 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lomotil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Rickets:

Rickets (1,087 drugs)

Browse all the conditions that are associated with Rickets:

Rickets (1,459 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on atropine sulfate; diphenoxylate hydrochloride (the active ingredients of Lomotil) and Lomotil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.