Loratadine and Sinus node dysfunction - a phase IV clinical study of FDA data

Summary:

Sinus node dysfunction is reported as a side effect among people who take Loratadine (loratadine), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Acetylsalicylic Acid, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Loratadine. It is created by eHealthMe based on reports of 53,991 people who have side effects when taking Loratadine from the FDA, and is updated regularly.

What is Loratadine?

Loratadine has active ingredients of loratadine. It is often used in allergies. eHealthMe is studying from 56,308 Loratadine users. Check the latest studies of Loratadine.

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,191 drugs and 840 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

On Jan, 19, 2026

53,991 people reported to have side effects when taking Loratadine.
Among them, 22 people (0.04%) have Sinus node dysfunction.

Could Loratadine cause Sinus node dysfunction?

Among these 22 people:

How long have people been on Loratadine when they have Sinus node dysfunction? *

What is the gender of people who have Sinus node dysfunction when taking Loratadine? *

female: 63.16 %
male: 36.84 %

What is the age of people who have Sinus node dysfunction when taking Loratadine? *

What are other drugs people take besides Loratadine? *

What are other side effects people have besides Sinus node dysfunction? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 8 people, 36.36%
Pneumonia: 6 people, 27.27%
Dyspnea Exertional: 5 people, 22.73%
Fever: 5 people, 22.73%
Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue): 4 people, 18.18%
Bradycardia (abnormally slow heart action): 2 people, 9.09%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 2 people, 9.09%
Diabetes Mellitus Inadequate Control: 1 person, 4.55%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 1 person, 4.55%
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body): 1 person, 4.55%

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 11 people, 50.00%
Dementia (madness): 10 people, 45.45%
Colorectal Cancer Stage Iii (colon and rectal cancer spreads to lymph nodes): 5 people, 22.73%
Urinary Tract Infection: 1 person, 4.55%
Panic Disorder: 1 person, 4.55%
Lung Cancer - Non-Small Cell (lung cancer): 1 person, 4.55%
High Blood Pressure: 1 person, 4.55%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Loratadine and have Sinus node dysfunction?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Loratadine:

Loratadine (56,308 reports)

Browse all side effects of Loratadine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus node dysfunction:

Sinus node dysfunction (1,191 drugs)

Browse all the conditions that are associated with Sinus node dysfunction:

Sinus node dysfunction (840 conditions)

Drugs similar to Loratadine and Sinus node dysfunction :

How the study uses the data?

The study uses data from the FDA. It is based on loratadine (the active ingredients of Loratadine) and Loratadine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.