Zyrtec and Sinus node dysfunction - a phase IV clinical study of FDA data

Summary:

Sinus node dysfunction is reported as a side effect among people who take Zyrtec (cetirizine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Digoxin, and have Narcolepsy.

The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Zyrtec. It is created by eHealthMe based on reports of 109,528 people who have side effects when taking Zyrtec from the FDA, and is updated regularly.

What is Zyrtec?

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. eHealthMe is studying from 114,607 Zyrtec users. Check the latest studies of Zyrtec.

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,266 drugs and 834 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

On Oct, 17, 2025

109,528 people reported to have side effects when taking Zyrtec.
Among them, 33 people (0.03%) have Sinus node dysfunction.

Could Zyrtec cause Sinus node dysfunction?

Among these 33 people:

How long have people been on Zyrtec when they have Sinus node dysfunction? *

What is the gender of people who have Sinus node dysfunction when taking Zyrtec? *

female: 51.52 %
male: 48.48 %

What is the age of people who have Sinus node dysfunction when taking Zyrtec? *

What are other drugs people take besides Zyrtec? *

What are other side effects people have besides Sinus node dysfunction? *

Bradycardia (abnormally slow heart action): 16 people, 48.48%
Dizziness: 15 people, 45.45%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 13 people, 39.39%
Dyspnea (difficult or laboured breathing): 11 people, 33.33%
Pain: 10 people, 30.30%
Pain In Extremity: 9 people, 27.27%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 9 people, 27.27%
Cardiac Disorder: 8 people, 24.24%
Cough: 8 people, 24.24%
Stress And Anxiety: 8 people, 24.24%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 15.15%
Oral Cancer (mouth cancer): 4 people, 12.12%
Itching: 4 people, 12.12%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 12.12%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 4 people, 12.12%
Arrhythmias (irregular heartbeat): 2 people, 6.06%
Cardiac Failure: 2 people, 6.06%
Heart Rate Irregular: 2 people, 6.06%
Gastritis (inflammation of stomach): 2 people, 6.06%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Zyrtec and have Sinus node dysfunction?

- Check whether Sinus node dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zyrtec:

Zyrtec (114,607 reports)

Browse all side effects of Zyrtec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus node dysfunction:

Sinus node dysfunction (1,266 drugs)

Browse all the conditions that are associated with Sinus node dysfunction:

Sinus node dysfunction (834 conditions)

Drugs similar to Zyrtec and Sinus node dysfunction :

How the study uses the data?

The study uses data from the FDA. It is based on cetirizine hydrochloride (the active ingredients of Zyrtec) and Zyrtec (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.