Lorazepam and Depressive symptom - a phase IV clinical study of FDA data

Summary:

Depressive symptom is reported as a side effect among people who take Lorazepam (lorazepam), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Mirtazapine, and have Depression.

The phase IV clinical study analyzes which people have Depressive symptom when taking Lorazepam. It is created by eHealthMe based on reports of 161,687 people who have side effects when taking Lorazepam from the FDA, and is updated regularly.

What is Lorazepam?

Lorazepam has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,639 Lorazepam users. Check the latest studies of Lorazepam.

What is Depressive symptom?

Depressive symptom is found to be associated with 465 drugs and 478 conditions by eHealthMe. Check the latest studies of Depressive symptom.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

161,687 people reported to have side effects when taking Lorazepam.
Among them, 79 people (0.05%) have Depressive symptom.

Could Lorazepam cause Depressive symptom?

Among these 79 people:

How long have people been on Lorazepam when they have Depressive symptom? *

What is the gender of people who have Depressive symptom when taking Lorazepam? *

female: 62.5 %
male: 37.5 %

What is the age of people who have Depressive symptom when taking Lorazepam? *

What are other drugs people take besides Lorazepam? *

What are other side effects people have besides Depressive symptom? *

Suicidal Ideation: 22 people, 27.85%
Agitation (state of anxiety or nervous excitement): 22 people, 27.85%
Psychotic Disorder: 16 people, 20.25%
Fatigue (feeling of tiredness): 16 people, 20.25%
Delirium (wild excitement): 13 people, 16.46%
Drug Ineffective: 11 people, 13.92%
Dizziness: 11 people, 13.92%
Hallucinations (sensations that appear real but are created by your mind): 8 people, 10.13%
Emotional Distress: 8 people, 10.13%
Weight Increased: 8 people, 10.13%

What are the existing conditions these people have? *

Depression: 17 people, 21.52%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 12 people, 15.19%
Parkinson's Disease: 9 people, 11.39%
Sleep Disorder: 8 people, 10.13%
High Blood Pressure: 8 people, 10.13%
Pain: 8 people, 10.13%
Constipation: 7 people, 8.86%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 8.86%
Psychotic Disorder: 6 people, 7.59%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 5 people, 6.33%

* Approximation only. Some reports may have incomplete information.

Do you take Lorazepam and have Depressive symptom?

- Check whether Depressive symptom is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lorazepam:

Lorazepam (165,639 reports)

Browse all side effects of Lorazepam:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depressive symptom:

Depressive symptom (465 drugs)

Browse all the conditions that are associated with Depressive symptom:

Depressive symptom (478 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lorazepam (the active ingredients of Lorazepam) and Lorazepam (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.