Lorcet-hd and Pathological fracture - a phase IV clinical study of FDA data

Summary:

Pathological fracture is reported as a side effect among people who take Lorcet-hd (acetaminophen; hydrocodone bitartrate), especially for people who are female, 50-59 old, also take Aredia, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Pathological fracture when taking Lorcet-hd. It is created by eHealthMe based on reports of 2,140 people who have side effects when taking Lorcet-hd from the FDA, and is updated regularly.

What is Lorcet-hd?

Lorcet-hd has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 2,221 Lorcet-hd users. Check the latest studies of Lorcet-hd.

What is Pathological fracture?

Pathological fracture (broken bone caused by disease) is found to be associated with 837 drugs and 541 conditions by eHealthMe. Check the latest studies of Pathological fracture.

On Jul, 14, 2026

2,140 people reported to have side effects when taking Lorcet-hd.
Among them, 16 people (0.75%) have Pathological fracture.

$Could Lorcet-hd cause Pathological fracture?$

Among these 16 people:

What is the gender of people who have Pathological fracture when taking Lorcet-hd? *

female: 87.5 %
male: 12.5 %

What is the age of people who have Pathological fracture when taking Lorcet-hd? *

What are other drugs people take besides Lorcet-hd? *

What are other side effects people have besides Pathological fracture? *

Oedema Peripheral (superficial swelling): 14 people, 87.50%
Agitation (state of anxiety or nervous excitement): 14 people, 87.50%
Diarrhea: 14 people, 87.50%
Nausea And Vomiting: 13 people, 81.25%
Nausea (feeling of having an urge to vomit): 13 people, 81.25%
Fungal Infection: 12 people, 75.00%
Myeloma Recurrence (recurrence of cancer of the plasma cells - a kind of white blood cell): 12 people, 75.00%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 12 people, 75.00%
Mental Impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 12 people, 75.00%
Injury: 12 people, 75.00%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 12 people, 75.00%
Stress And Anxiety: 2 people, 12.50%
Osteoporosis (bones weak and more likely to break): 2 people, 12.50%
High Blood Pressure: 1 person, 6.25%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 6.25%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Lorcet-hd and have Pathological fracture?

- Check whether Pathological fracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lorcet-hd:

Lorcet-hd (2,221 reports)

Pathological fracture treatments and more:

Pathological fracture (7,718 reports)

How severe was Pathological fracture and when was it recovered:

Pathological fracture in Lorcet-hd

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Pathological fracture and drugs with ingredients of acetaminophen; hydrocodone bitartrate (492 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lorcet-hd:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pathological fracture:

Pathological fracture (837 drugs)

Browse all the conditions that are associated with Pathological fracture:

Pathological fracture (541 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Lorcet-hd) and Lorcet-hd (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.