Lorcet-hd and Rectal haemorrhage - a phase IV clinical study of FDA data

Summary:

Rectal haemorrhage is reported as a side effect among people who take Lorcet-hd (acetaminophen; hydrocodone bitartrate), especially for people who are female, 60+ old, also take Neurontin, and have Metastases to bone.

The phase IV clinical study analyzes which people have Rectal haemorrhage when taking Lorcet-hd. It is created by eHealthMe based on reports of 2,140 people who have side effects when taking Lorcet-hd from the FDA, and is updated regularly.

What is Lorcet-hd?

Lorcet-hd has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 2,221 Lorcet-hd users. Check the latest studies of Lorcet-hd.

What is Rectal haemorrhage?

Rectal haemorrhage (bleeding from anus) is found to be associated with 1,725 drugs and 1,597 conditions by eHealthMe. Check the latest studies of Rectal haemorrhage.

On Aug, 11, 2026

2,140 people reported to have side effects when taking Lorcet-hd.
Among them, 44 people (2.06%) have Rectal haemorrhage.

Could Lorcet-hd cause Rectal haemorrhage?

Among these 44 people:

What is the gender of people who have Rectal haemorrhage when taking Lorcet-hd? *

female: 65.91 %
male: 34.09 %

What is the age of people who have Rectal haemorrhage when taking Lorcet-hd? *

What are other drugs people take besides Lorcet-hd? *

What are other side effects people have besides Rectal haemorrhage? *

Joint Pain: 30 people, 68.18%
Pain In Extremity: 25 people, 56.82%
Constipation: 24 people, 54.55%
Headache (pain in head): 24 people, 54.55%
Anaemia (lack of blood): 24 people, 54.55%
Chest Pain: 23 people, 52.27%
Weight Decreased: 22 people, 50.00%
Fatigue (feeling of tiredness): 22 people, 50.00%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 21 people, 47.73%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 20 people, 45.45%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 18 people, 40.91%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.82%
Cardiac Disorder: 3 people, 6.82%
Stress And Anxiety: 2 people, 4.55%
Depression: 2 people, 4.55%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 1 person, 2.27%
Acne (skin problems that cause pimples): 1 person, 2.27%
Asthma: 1 person, 2.27%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 2.27%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 2.27%

* Approximation only. Some reports may have incomplete information.

Do you take Lorcet-hd and have Rectal haemorrhage?

- Check whether Rectal haemorrhage is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lorcet-hd:

Lorcet-hd (2,221 reports)

Rectal haemorrhage treatments and more:

Rectal haemorrhage (56,949 reports)

How severe was Rectal haemorrhage and when was it recovered:

Rectal haemorrhage in Lorcet-hd

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Rectal haemorrhage and drugs with ingredients of acetaminophen; hydrocodone bitartrate (1,329 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lorcet-hd:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Rectal haemorrhage:

Rectal haemorrhage (1,725 drugs)

Browse all the conditions that are associated with Rectal haemorrhage:

Rectal haemorrhage (1,597 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Lorcet-hd) and Lorcet-hd (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.