Losartan and Leukoencephalopathy - a phase IV clinical study of FDA data

Summary:

Leukoencephalopathy is reported as a side effect among people who take Losartan (losartan potassium), especially for people who are female, 60+ old, also take Amlodipine, and have Lung cancer - non-small cell.

The phase IV clinical study analyzes which people have Leukoencephalopathy when taking Losartan. It is created by eHealthMe based on reports of 170,768 people who have side effects when taking Losartan from the FDA, and is updated regularly.

What is Losartan?

Losartan has active ingredients of losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 177,686 Losartan users. Check the latest studies of Losartan.

What is Leukoencephalopathy?

Leukoencephalopathy (disease of the white matter in the brain) is found to be associated with 384 drugs and 626 conditions by eHealthMe. Check the latest studies of Leukoencephalopathy.

On Jul, 25, 2026

170,768 people reported to have side effects when taking Losartan.
Among them, 27 people (0.02%) have Leukoencephalopathy.

Could Losartan cause Leukoencephalopathy?

Among these 27 people:

What is the gender of people who have Leukoencephalopathy when taking Losartan? *

female: 70.83 %
male: 29.17 %

What is the age of people who have Leukoencephalopathy when taking Losartan? *

What are other drugs people take besides Losartan? *

What are other side effects people have besides Leukoencephalopathy? *

Weakness: 6 people, 22.22%
Drowsiness: 6 people, 22.22%
Nausea (feeling of having an urge to vomit): 5 people, 18.52%
Dizziness: 5 people, 18.52%
Microangiopathy (disease of the capillaries (very small blood vessels), in which the capillary walls become so thick and weak that they bleed, leak protein): 5 people, 18.52%
Weight Decreased: 4 people, 14.81%
Confusion: 4 people, 14.81%
Nasopharyngitis (inflammation of the nasopharynx): 4 people, 14.81%
Monoclonal Gammopathy: 4 people, 14.81%
Nosebleed (bleeding from nose): 4 people, 14.81%

What are the existing conditions these people have? *

Breast Cancer Metastatic: 4 people, 14.81%
Chronic Kidney Disease: 4 people, 14.81%
Lung Cancer - Non-Small Cell (lung cancer): 4 people, 14.81%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 11.11%
Multiple Myeloma (cancer of the plasma cells): 2 people, 7.41%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 2 people, 7.41%
Enlarged Prostate: 2 people, 7.41%
Bone Pain: 2 people, 7.41%
Diabetes: 2 people, 7.41%
Urinary Tract Infection: 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Losartan and have Leukoencephalopathy?

- Check whether Leukoencephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Losartan:

Losartan (177,686 reports)

Browse all side effects of Losartan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Leukoencephalopathy:

Leukoencephalopathy (384 drugs)

Browse all the conditions that are associated with Leukoencephalopathy:

Leukoencephalopathy (626 conditions)

Related publications that referenced our studies

Lai SW, Lin HF, Lin CL, Liao KF, "No association between losartan use and acute pancreatitis in hypertensive patients", Eur J Hosp Pharm, 2017 Mar .
Lai SW, Lin HF, Lin CL, Liao KF, "No association between losartan use and acute pancreatitis in hypertensive patients", Eur J Hosp Pharm, 2017 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on losartan potassium (the active ingredients of Losartan) and Losartan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.