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Amlodipine and Pifeltro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amlodipine (amlodipine besylate) and Pifeltro (doravirine). Common drug interactions include anhedonia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Amlodipine and Pifeltro. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Amlodipine?

Amlodipine has active ingredients of amlodipine besylate. It is often used in high blood pressure. eHealthMe is studying from 354,829 Amlodipine users. Check the latest studies of Amlodipine.

What is Pifeltro?

Pifeltro has active ingredients of doravirine. eHealthMe is studying from 476 Pifeltro users. Check the latest studies of Pifeltro.

On Jul, 25, 2026

25 people who take Amlodipine and Pifeltro together, and have interactions are studied.

Amlodipine and Pifeltro drug interactions.

What are the common drug interactions of Amlodipine and Pifeltro, by gender? *:

female:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Emotional distress
  4. Pain
  5. Chronic kidney disease
  6. Anaemia (lack of blood)
  7. Cardiac disorder
  8. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  9. Dementia (madness)
  10. Gait disturbance

male:

  1. Chronic kidney disease
  2. Pain
  3. Osteoporosis (bones weak and more likely to break)
  4. Hallucination (an experience involving the perception of something not present)
  5. Bone density decreased
  6. Dysstasia (difficulty in standing)
  7. Gait disturbance
  8. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  9. Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
  10. Renal impairment (severely reduced kidney function)

What are the common drug interactions of Amlodipine and Pifeltro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Bone density decreased
  4. Chronic kidney disease
  5. Emotional distress
  6. Pain
  7. Renal failure (kidney dysfunction)
  8. Tooth loss

30-39:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Emotional distress
  4. Fatigue (feeling of tiredness)
  5. Pain
  6. Quality of life decreased
  7. Renal failure (kidney dysfunction)

40-49:

  1. Beta 2 microglobulin urine increased
  2. Haemorrhagic diathesis (bleeding tendency)
  3. Hyperuricaemia (level of uric acid in the blood that is abnormally high)
  4. Liver disorder (liver diseases)
  5. Osteoporosis (bones weak and more likely to break)
  6. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  7. Anxiety
  8. Chronic kidney disease
  9. Emotional distress
  10. Pain

50-59:

  1. Chronic kidney disease
  2. Pain
  3. Emotional distress
  4. Renal failure (kidney dysfunction)
  5. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  6. Anxiety
  7. Blood creatinine increased
  8. Anaemia (lack of blood)
  9. Arthralgia (joint pain)
  10. Asthenia (weakness)

60+:

  1. Hallucination (an experience involving the perception of something not present)
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Pain
  4. Renal impairment (severely reduced kidney function)
  5. Glomerulosclerosis (a hardening of the glomerulus in the kidney)
  6. International normalised ratio increased
  7. Anxiety
  8. Chronic kidney disease
  9. Death
  10. Dysstasia (difficulty in standing)

What are the existing conditions these people have? *

  1. Hiv Infection: 20 people, 80.00%
  2. Depression: 4 people, 16.00%
  3. Stress And Anxiety: 3 people, 12.00%
  4. Hiv Test Positive: 3 people, 12.00%
  5. Acne (skin problems that cause pimples): 3 people, 12.00%
  6. Erection Problems: 3 people, 12.00%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 12.00%
  8. Hepatitis (inflammation of the liver): 3 people, 12.00%
  9. Hyperuricaemia (level of uric acid in the blood that is abnormally high): 3 people, 12.00%
  10. Seborrheic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 3 people, 12.00%

* Approximation only. Some reports may have incomplete information.

Do you take Amlodipine and Pifeltro?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Amlodipine and Pifeltro:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Amlodipine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Pifeltro:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Amlodipine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Pifeltro and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on amlodipine besylate and doravirine (the active ingredients of Amlodipine and Pifeltro, respectively), and Amlodipine and Pifeltro (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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