Valacyclovir hydrochloride and Glucophage drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valacyclovir hydrochloride (valacyclovir hydrochloride) and Glucophage (metformin hydrochloride). Common drug interactions include cholestatic liver injury among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Valacyclovir hydrochloride and Glucophage. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Valacyclovir hydrochloride?

Valacyclovir hydrochloride has active ingredients of valacyclovir hydrochloride. It is often used in herpes zoster. eHealthMe is studying from 12,929 Valacyclovir hydrochloride users. Check the latest studies of Valacyclovir hydrochloride.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.

On Jul, 25, 2026

49 people who take Valacyclovir hydrochloride and Glucophage together, and have interactions are studied.

Valacyclovir hydrochloride and Glucophage drug interactions.

What are the common drug interactions of Valacyclovir Hydrochloride and Glucophage, by gender? *:

female:

Cholestatic liver injury (due to injury bile cannot floe from liver)
Renal tubular disorder (disease of kidney tubules)
Fall
Hysterectomy
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Deafness
Dizziness
Escherichia infection (bacterial infection by escherichia coli)
Hypersensitivity
Hypertension (high blood pressure)

male:

Dehydration (dryness resulting from the removal of water)
Dysarthria (speech disorder)
Pyrexia (fever)
Skin hypertrophy (skin cells enlarges)
Skin wound
Soft tissue infection
Swelling
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Hypovolaemic shock (shock caused by severe blood or fluid loss)
Renal failure (kidney dysfunction)

What are the common drug interactions of Valacyclovir Hydrochloride and Glucophage, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Arthralgia (joint pain)
Blood creatine phosphokinase increased

60+:

Cholestatic liver injury (due to injury bile cannot floe from liver)
Renal tubular disorder (disease of kidney tubules)
Concussion (short loss of normal brain function in response to a head injury)
Erythema (redness of the skin)
Febrile neutropenia (fever with reduced white blood cells)
Hepatitis b
Pain
Pneumonia
Psoas abscess (collection of pus in the iliopsoas muscle compartment)
Purulent discharge (discharge that contains pus)

What are the existing conditions these people have? *

High Blood Pressure: 22 people, 44.90%
Arrhythmias (irregular heartbeat): 13 people, 26.53%
Dyslipidaemia (abnormal amount of lipids): 12 people, 24.49%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 10 people, 20.41%
Back Pain: 10 people, 20.41%
Multiple Myeloma (cancer of the plasma cells): 10 people, 20.41%
Sleep Disorder: 10 people, 20.41%
Oesophagitis (inflammation of oesophagus): 10 people, 20.41%
Neuralgia (pain in one or more nerves): 8 people, 16.33%
Type 2 Diabetes: 7 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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