Loxapine succinate and Death - a phase IV clinical study of FDA data

Summary:

Death is reported as a side effect among people who take Loxapine succinate (loxapine succinate), especially for people who are male, 30-39 old, have been taking the drug for < 1 month also take Fluoxetine Hydrochloride, and have Agitation.

The study is created by eHealthMe based on reports of 1,088 people who have side effects when taking Loxapine succinate from the FDA, and is updated regularly.

What is Loxapine succinate?

Loxapine succinate has active ingredients of loxapine succinate. eHealthMe is studying from 1,096 Loxapine succinate users. Check the latest studies of Loxapine succinate.

On Aug, 11, 2026

1,088 people reported to have side effects when taking Loxapine succinate.
Among them, 48 people (4.41%) died.

Among these 48 people:

How long have people been on Loxapine succinate when they died? *

What is the gender of people who died when taking Loxapine succinate? *

female: 37.21 %
male: 62.79 %

What is the age of people who died when taking Loxapine succinate? *

What are other drugs people take besides Loxapine succinate? *

Fluoxetine Hydrochloride: 8 people, 16.67%
Zyprexa: 6 people, 12.50%
Methadone Hydrochloride: 6 people, 12.50%
Paracetamol: 5 people, 10.42%
Risperidone: 5 people, 10.42%
Zopiclone: 5 people, 10.42%
Bisoprolol Fumarate: 4 people, 8.33%
Clozapine: 4 people, 8.33%
Haloperidol: 3 people, 6.25%
Metformin Hydrochloride: 3 people, 6.25%

What are other side effects people have before they died? *

Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body): 6 people, 12.50%
Haemodynamic Instability (disturbances in the blood movement in our body): 2 people, 4.17%
Speech Impairment (Adult) (inability to speak (adult)): 2 people, 4.17%
Salivary Hypersecretion (excess saliva secretion): 2 people, 4.17%
Drug Level Increased: 2 people, 4.17%
Disturbance In Attention: 2 people, 4.17%
Aggression: 2 people, 4.17%
Neuroleptic Malignant Syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 2 people, 4.17%
Dyskinesia (abnormality or impairment of voluntary movement): 1 person, 2.08%
Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 1 person, 2.08%

What are the existing conditions these people have? *

Agitation (state of anxiety or nervous excitement): 6 people, 12.50%
Cardiac Failure: 3 people, 6.25%
Depression: 3 people, 6.25%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 4.17%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 2 people, 4.17%
Vitamin D Decreased: 1 person, 2.08%
Constipation: 1 person, 2.08%
Arrhythmias (irregular heartbeat): 1 person, 2.08%
Bipolar Disorder (mood disorder): 1 person, 2.08%
Cardiomyopathy (weakening of the heart muscle): 1 person, 2.08%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Loxapine succinate:

Loxapine succinate (1,096 reports)

Expand to all the drugs that have ingredients of loxapine succinate:

Death and drugs with ingredients of loxapine succinate (266 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Loxapine succinate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Death:

Death (3,115 drugs)

Browse all the conditions that are associated with Death:

Death (3,686 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on loxapine succinate (the active ingredients of Loxapine succinate) and Loxapine succinate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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