Lybalvi and Fatigue - a phase IV clinical study of FDA data

Summary:

Fatigue is reported as a side effect among people who take Lybalvi (olanzapine; samidorphan l-malate), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Olanzapine, and have Bipolar i disorder.

The phase IV clinical study analyzes which people have Fatigue when taking Lybalvi. It is created by eHealthMe based on reports of 872 people who have side effects when taking Lybalvi from the FDA, and is updated regularly.

What is Lybalvi?

Lybalvi has active ingredients of olanzapine; samidorphan l-malate. eHealthMe is studying from 874 Lybalvi users. Check the latest studies of Lybalvi.

What is Fatigue?

Fatigue (feeling of tiredness) is found to be associated with 4,027 drugs and 6,380 conditions by eHealthMe. Check the latest studies of Fatigue.

On Jul, 18, 2026

872 people reported to have side effects when taking Lybalvi.
Among them, 43 people (4.93%) have Fatigue.

Among these 43 people:

How long have people been on Lybalvi when they have Fatigue? *

What is the gender of people who have Fatigue when taking Lybalvi? *

female: 55.88 %
male: 44.12 %

What is the age of people who have Fatigue when taking Lybalvi? *

What are other drugs people take besides Lybalvi? *

What are other side effects people have besides Fatigue? *

Drowsiness: 12 people, 27.91%
Dizziness: 7 people, 16.28%
Feeling Abnormal: 7 people, 16.28%
Confusion: 6 people, 13.95%
Weakness: 5 people, 11.63%
Sedation: 5 people, 11.63%
Hallucinations (sensations that appear real but are created by your mind): 4 people, 9.30%
Tremor (trembling or shaking movements in one or more parts of your body): 4 people, 9.30%
Loss Of Consciousness: 4 people, 9.30%
Stress And Anxiety: 3 people, 6.98%

What are the existing conditions these people have? *

Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 7 people, 16.28%
Bipolar Disorder (mood disorder): 5 people, 11.63%
Psychotic Disorder: 4 people, 9.30%
Stress And Anxiety: 3 people, 6.98%
Back Pain: 3 people, 6.98%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 6.98%
Weight Increased: 2 people, 4.65%
Schizoaffective Disorder Bipolar Type (mental illness featuring schizophrenia and a mood disorder with mania): 2 people, 4.65%
Hypersensitivity: 2 people, 4.65%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 2 people, 4.65%

* Approximation only. Some reports may have incomplete information.

Do you take Lybalvi and have Fatigue?

- Check whether Fatigue is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lybalvi:

Lybalvi (874 reports)

Fatigue treatments and more:

Fatigue (967,537 reports)

How severe was Fatigue and when was it recovered:

Fatigue in Lybalvi

Expand to all the drugs that have ingredients of olanzapine; samidorphan l-malate:

Fatigue and drugs with ingredients of olanzapine; samidorphan l-malate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lybalvi:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fatigue:

Fatigue (4,027 drugs)

Browse all the conditions that are associated with Fatigue:

Fatigue (6,380 conditions)

Related publications that referenced our studies

Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W, "A randomized controlled trial of coenzyme Q 10 for fatigue in the late-onset sequelae of poliomyelitis", Complementary therapies in medicine, 2015 Dec .
Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W, "A randomized controlled trial of coenzyme Q 10 for fatigue in the late-onset sequelae of poliomyelitis", Complementary therapies in medicine, 2015 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on olanzapine; samidorphan l-malate (the active ingredients of Lybalvi) and Lybalvi (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.