Lybalvi and Weight increased - a phase IV clinical study of FDA data

Summary:

Weight increased is reported as a side effect among people who take Lybalvi (olanzapine; samidorphan l-malate), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Olanzapine, and have Bipolar disorder.

The phase IV clinical study analyzes which people have Weight increased when taking Lybalvi. It is created by eHealthMe based on reports of 872 people who have side effects when taking Lybalvi from the FDA, and is updated regularly.

What is Lybalvi?

Lybalvi has active ingredients of olanzapine; samidorphan l-malate. eHealthMe is studying from 874 Lybalvi users. Check the latest studies of Lybalvi.

What is Weight increased?

Weight increased is found to be associated with 2,885 drugs and 3,953 conditions by eHealthMe. Check the latest studies of Weight increased.

On Jul, 18, 2026

872 people reported to have side effects when taking Lybalvi.
Among them, 31 people (3.56%) have Weight increased.

Among these 31 people:

How long have people been on Lybalvi when they have Weight increased? *

What is the gender of people who have Weight increased when taking Lybalvi? *

female: 62.96 %
male: 37.04 %

What is the age of people who have Weight increased when taking Lybalvi? *

What are other drugs people take besides Lybalvi? *

What are other side effects people have besides Weight increased? *

Drowsiness: 6 people, 19.35%
Appetite - Increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 5 people, 16.13%
Depression: 4 people, 12.90%
Tremor (trembling or shaking movements in one or more parts of your body): 4 people, 12.90%
Sedation: 3 people, 9.68%
Stress And Anxiety: 3 people, 9.68%
Peripheral Swelling: 2 people, 6.45%
Memory Loss: 2 people, 6.45%
Confusional State: 2 people, 6.45%
Mania (a state of abnormally elevated or irritable mood): 2 people, 6.45%

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 9 people, 29.03%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 5 people, 16.13%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 4 people, 12.90%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 2 people, 6.45%
Affective Disorder (mental disorder): 2 people, 6.45%
Type 2 Diabetes: 1 person, 3.23%
Stress And Anxiety: 1 person, 3.23%
Schizoaffective Disorder Bipolar Type (mental illness featuring schizophrenia and a mood disorder with mania): 1 person, 3.23%
Insomnia (sleeplessness): 1 person, 3.23%
High Blood Pressure: 1 person, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Lybalvi and have Weight increased?

- Check whether Weight increased is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lybalvi:

Lybalvi (874 reports)

Weight increased treatments and more:

Weight increased (279,369 reports)

How severe was Weight increased and when was it recovered:

Weight increased in Lybalvi

Expand to all the drugs that have ingredients of olanzapine; samidorphan l-malate:

Weight increased and drugs with ingredients of olanzapine; samidorphan l-malate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lybalvi:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Weight increased:

Weight increased (2,885 drugs)

Browse all the conditions that are associated with Weight increased:

Weight increased (3,953 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on olanzapine; samidorphan l-malate (the active ingredients of Lybalvi) and Lybalvi (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.