Lyrica and Multiple system atrophy - a phase IV clinical study of FDA data

Summary:

Multiple system atrophy is reported as a side effect among people who take Lyrica (pregabalin), especially for people who are female, 40-49 old, also take Keppra, and have Drowsiness.

The phase IV clinical study analyzes which people have Multiple system atrophy when taking Lyrica. It is created by eHealthMe based on reports of 255,839 people who have side effects when taking Lyrica from the FDA, and is updated regularly.

What is Lyrica?

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 261,646 Lyrica users. Check the latest studies of Lyrica.

What is Multiple system atrophy?

Multiple system atrophy (degeneration of nerve cells in specific areas of the brain) is found to be associated with 67 drugs and 333 conditions by eHealthMe. Check the latest studies of Multiple system atrophy.

On Jul, 30, 2026

255,839 people reported to have side effects when taking Lyrica.
Among them, 12 people (0.0%) have Multiple system atrophy.

Could Lyrica cause Multiple system atrophy?

Among these 12 people:

What is the gender of people who have Multiple system atrophy when taking Lyrica? *

female: 75 %
male: 25 %

What is the age of people who have Multiple system atrophy when taking Lyrica? *

What are other drugs people take besides Lyrica? *

What are other side effects people have besides Multiple system atrophy? *

Sleep Apnea Syndrome: 8 people, 66.67%
Headache (pain in head): 7 people, 58.33%
Insomnia (sleeplessness): 7 people, 58.33%
Crying: 7 people, 58.33%
Rebound Effect (take-back effect): 6 people, 50.00%
Movement - Uncoordinated: 4 people, 33.33%
Neuropathy Peripheral (surface nerve damage): 4 people, 33.33%
Drug Ineffective: 3 people, 25.00%
Hypotension (abnormally low blood pressure): 3 people, 25.00%
Hepatic Steatosis (fatty liver disease): 3 people, 25.00%

What are the existing conditions these people have? *

Drowsiness: 7 people, 58.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 50.00%
Hypotension (abnormally low blood pressure): 6 people, 50.00%
Hypersensitivity: 6 people, 50.00%
Oral Herpes (viral infection of mouth): 5 people, 41.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 41.67%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 5 people, 41.67%
Migraine (headache): 5 people, 41.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 41.67%
Bipolar Disorder (mood disorder): 5 people, 41.67%

* Approximation only. Some reports may have incomplete information.

Do you take Lyrica and have Multiple system atrophy?

- Check whether Multiple system atrophy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lyrica:

Lyrica (261,646 reports)

Browse all side effects of Lyrica:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple system atrophy:

Multiple system atrophy (67 drugs)

Browse all the conditions that are associated with Multiple system atrophy:

Multiple system atrophy (333 conditions)

Related publications that referenced our studies

de Landaluce, L. O., Carbonell, P., Asensio, C., Escoda, N., López, P., & Laporte, J. R. , "Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database", Drug safety, 2018 Jan .
Bonnet U, Taazimi B, Grabbe HD, "Pregabalin-Related Hypertriglyceridemia", Psychosomatics, 2014 Nov .
de Landaluce, L. O., Carbonell, P., Asensio, C., Escoda, N., López, P., & Laporte, J. R. , "Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database", Drug safety, 2018 Jan .
Bonnet U, Taazimi B, Grabbe HD, "Pregabalin-Related Hypertriglyceridemia", Psychosomatics, 2014 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on pregabalin (the active ingredients of Lyrica) and Lyrica (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.