Macrobid and Aortic stenosis - a phase IV clinical study of FDA data

Summary:

Aortic stenosis is reported as a side effect among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline), especially for people who are female, 60+ old, also take Ibuprofen, and have Depression.

The phase IV clinical study analyzes which people have Aortic stenosis when taking Macrobid. It is created by eHealthMe based on reports of 8,335 people who have side effects when taking Macrobid from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Aortic stenosis?

Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta) is found to be associated with 778 drugs and 972 conditions by eHealthMe. Check the latest studies of Aortic stenosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

8,335 people reported to have side effects when taking Macrobid.
Among them, 15 people (0.18%) have Aortic stenosis.

Among these 15 people:

What is the gender of people who have Aortic stenosis when taking Macrobid? *

female: 60 %
male: 40 %

What is the age of people who have Aortic stenosis when taking Macrobid? *

What are other drugs people take besides Macrobid? *

Ibuprofen: 7 people, 46.67%
Vicodin: 6 people, 40.00%
Tylenol: 5 people, 33.33%
Paxil: 5 people, 33.33%
Vistaril: 5 people, 33.33%
Flonase: 4 people, 26.67%
Effexor Xr: 4 people, 26.67%
Cephalexin: 4 people, 26.67%
Pyridium: 4 people, 26.67%
Sulfamethoxazole And Trimethoprim: 4 people, 26.67%

What are other side effects people have besides Aortic stenosis? *

Aortic Valve Incompetence: 10 people, 66.67%
Cardiac Murmur (an heart sound in valve abnormality): 9 people, 60.00%
Tricuspid Valve Incompetence (inefficient heart valve): 9 people, 60.00%
Drug Exposure During Pregnancy: 9 people, 60.00%
Chest Pain: 7 people, 46.67%
Fatigue (feeling of tiredness): 7 people, 46.67%
Tachypnea: 7 people, 46.67%
Bradycardia (abnormally slow heart action): 7 people, 46.67%
Dyspnea (difficult or laboured breathing): 7 people, 46.67%
Skin Discoloration - Bluish (bluish colour of skin): 6 people, 40.00%

What are the existing conditions these people have? *

Depression: 5 people, 33.33%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 20.00%
Joint Pain: 3 people, 20.00%
Multiple Myeloma (cancer of the plasma cells): 1 person, 6.67%
Diabetic Gastroparesis (paralysis of the muscles of the stomach caused by diabetes): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Macrobid and have Aortic stenosis?

- Check whether Aortic stenosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macrobid:

Macrobid (9,215 reports)

Aortic stenosis treatments and more:

Aortic stenosis (8,138 reports)

How severe was Aortic stenosis and when was it recovered:

Aortic stenosis in Macrobid

Expand to all the drugs that have ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline:

Aortic stenosis and drugs with ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline (15 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Macrobid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aortic stenosis:

Aortic stenosis (778 drugs)

Browse all the conditions that are associated with Aortic stenosis:

Aortic stenosis (972 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin; nitrofurantoin, macrocrystalline (the active ingredients of Macrobid) and Macrobid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.