Macrobid and Pericardial effusion - a phase IV clinical study of FDA data

Summary:

Pericardial effusion is reported as a side effect among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Dexamethasone, and have Depression.

The phase IV clinical study analyzes which people have Pericardial effusion when taking Macrobid. It is created by eHealthMe based on reports of 8,335 people who have side effects when taking Macrobid from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Pericardial effusion?

Pericardial effusion (fluid around the heart) is found to be associated with 1,403 drugs and 1,462 conditions by eHealthMe. Check the latest studies of Pericardial effusion.

On Jul, 23, 2026

8,335 people reported to have side effects when taking Macrobid.
Among them, 27 people (0.32%) have Pericardial effusion.

Could Macrobid cause Pericardial effusion?

Among these 27 people:

How long have people been on Macrobid when they have Pericardial effusion? *

What is the gender of people who have Pericardial effusion when taking Macrobid? *

female: 54.17 %
male: 45.83 %

What is the age of people who have Pericardial effusion when taking Macrobid? *

What are other drugs people take besides Macrobid? *

What are other side effects people have besides Pericardial effusion? *

Fatigue (feeling of tiredness): 18 people, 66.67%
Chest Pain: 17 people, 62.96%
Weakness: 15 people, 55.56%
Pleural Effusion (water on the lungs): 15 people, 55.56%
Dyspnea (difficult or laboured breathing): 15 people, 55.56%
Hypotension (abnormally low blood pressure): 14 people, 51.85%
Mitral Valve Incompetence (inefficient heart valve): 13 people, 48.15%
Back Pain: 13 people, 48.15%
Stress And Anxiety: 12 people, 44.44%
Fever: 12 people, 44.44%

What are the existing conditions these people have? *

Depression: 7 people, 25.93%
Multiple Myeloma (cancer of the plasma cells): 5 people, 18.52%
Bladder Cancer: 3 people, 11.11%
Pain: 3 people, 11.11%
Abdominal Pain: 2 people, 7.41%
Diarrhea: 2 people, 7.41%
Dry Skin: 2 people, 7.41%
Colitis (inflammation of colon): 2 people, 7.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.41%
Glaucoma (increased fluid pressure in the eye with vision loss): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Macrobid and have Pericardial effusion?

- Check whether Pericardial effusion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macrobid:

Macrobid (9,215 reports)

Pericardial effusion treatments and more:

Pericardial effusion (29,052 reports)

How severe was Pericardial effusion and when was it recovered:

Pericardial effusion in Macrobid

Expand to all the drugs that have ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline:

Pericardial effusion and drugs with ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline (35 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Macrobid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pericardial effusion:

Pericardial effusion (1,403 drugs)

Browse all the conditions that are associated with Pericardial effusion:

Pericardial effusion (1,462 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin; nitrofurantoin, macrocrystalline (the active ingredients of Macrobid) and Macrobid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.